Actively Recruiting
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping
Led by University of Dundee · Updated on 2023-03-22
1000
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Bronchiectasis is a complex heterogeneous disorder. Treatment is challenging and many recent randomized controlled trials have been negative. It is believed that bronchiectasis as a broad diagnosis incorporates multiple different patient subgroups (also known as phenotypes) and molecular entities (referred to as endotypes). This study aims to phenotype and endotype bronchiectasis during stable disease and exacerbations, to develop strategies for personalised medicine. Primary Objective To determine molecular endotypes of bronchiectasis which can guide response to treatment. Secondary Objectives 1. To determine molecular endotypes of stable bronchiectasis 2. To determine the causes and inflammatory profiles of bronchiectasis exacerbations 3. To validate candidate biomarkers of stable and exacerbation endotypes to use in stratified medicine 4. To perform in-vivo or in-vitro proof of concept studies using phenotypic data to identify patient populations likely to benefit in future randomized controlled trials This is an observational cohort study that will aim to identify patient subgroups and link these with meaningful clinical outcomes.
CONDITIONS
Official Title
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A previous CT scan showing bronchiectasis along with compatible clinical syndrome of cough, sputum production and/or recurrent respiratory tract infections.
- A primary diagnosis of bronchiectasis made by a respiratory physician
- Clinically stable for 4 weeks before screening without treatment with antibiotics or corticosteroids for a pulmonary exacerbation
You will not qualify if you...
- Inability to give informed consent
- Younger than 18 years of age
- Patients with active tuberculosis
- Treatment with antibiotics or corticosteroids for a pulmonary exacerbation in the previous 4 weeks
- Bronchiectasis due to cystic fibrosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Dundee
Dundee, United Kingdom, DD1 9SY
Actively Recruiting
Research Team
J
James D Chalmers, MD, PhD
CONTACT
A
Amelia Shoemark, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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