Actively Recruiting
Efficacy of Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)
Led by University of Washington · Updated on 2026-04-14
800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating an integrated approach to reduce alcohol and marijuana use, related problems, and improve sleep among young adults who experience heavy episodic drinking, cannabis misuse, and sleep difficulties. This study focuses on young adults aged 18 to 29 with these overlapping challenges, as these issues can lead to injuries, academic and work problems, mental health risks, and impaired decision-making. The study aims to address gaps by combining brief interventions targeting alcohol, cannabis, and sleep in a community sample. Participants are randomly assigned to one of four groups: an integrated intervention combining alcohol/cannabis feedback with brief behavioral therapy for insomnia (BASICSSLEEP), a brief alcohol and cannabis intervention alone (BASICS+), a brief behavioral therapy for insomnia alone (SLEEP), or an attention control group. The active interventions include two initial sessions of 45-75 minutes and two booster phone sessions over time, delivered via telehealth. The attention control group attends four weekly 20-minute check-ins and receives referrals as needed. After the 18-month follow-up, control participants are offered the integrated BASICSSLEEP intervention. Participants complete surveys and daily diaries assessing alcohol, cannabis use, and sleep at baseline, post-intervention (7 weeks), and follow-ups at 3, 6, 12, and 18 months. Outcome measures include the Insomnia Severity Index, sleep-related impairment scales, and various alcohol use and consequences questionnaires. Secondary assessments monitor marijuana use and related consequences. The study tracks service use and provides community referrals to support participants throughout the research period, which runs until April 2029.
CONDITIONS
Brief Title
Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 18 and 29 years old
- Reside in Washington State
- Have a valid email address
- Score 10 or higher on the Insomnia Severity Index, indicating moderate or worse insomnia symptoms
- Report at least two heavy drinking episodes (4+ drinks for women/gender diverse, 5+ drinks for men within 2 hours) in the past month, or one heavy drinking episode plus at least four total drinking occasions in the past month
- Have used cannabis at least 4 times in the past month
- Did not participate in the prior R34 pilot feasibility trial
You will not qualify if you...
- Not meeting all inclusion criteria
- Declining or unable to consent to participate further in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person or virtual)
Duration - Approximately 7 weeks
Participants receive one of the four behavioral interventions designed to reduce alcohol and cannabis use and improve sleep. Treatments involve 2 sessions of 45 to 75 minutes each, with 2 brief telephone booster sessions for some interventions, delivered via telehealth.
2 in-person or virtual sessions and 2 telephone booster sessions
Duration - Up to 18 months post-treatment
Participants complete surveys and daily diaries assessing alcohol use, cannabis use, and sleep at multiple timepoints after treatment to evaluate the intervention effects over time.
Assessments at post-intervention, 3, 6, 12, and 18 months post-baseline
Trial Site Locations
Total: 1 location
1
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
M
Mary E Larimer, Ph.D.
N
Nicole Fossos-Wong, B.S.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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