Actively Recruiting
Bright Light Exposure in Surgical Patients
Led by University of Colorado, Denver · Updated on 2025-05-14
70
Participants Needed
1
Research Sites
363 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize that light therapy leads to Per2 dependent metabolic optimization in the human cardiac tissue. Therefore, a small piece of human heart tissue from the right atrium will be collected during cardiac cannulation, which will be otherwise discarded. 2. Critical illness (being in the intensive care unit) results in circadian malfunction and vessels not working. Vessel function is controlled by the body's circadian clock. Intense light boosts the circadian clock and the vessel function in animal studies. Vessels not working well in critical ill patients results in a myriad of severe diseases (delirium, stroke, heart attack, organ damage etc). Thus we will test if intense light can be used to boost the circadian clock and the associated vessel function in critical ill patients.
CONDITIONS
Official Title
Bright Light Exposure in Surgical Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing primary sternotomy cardiac surgery
- Age between 18 and 90 years old
- Patient must be in sinus rhythm at the time of surgery
You will not qualify if you...
- Under 18 or over 90 years old
- Participation in other clinical trials within the previous 30 days
- Pregnancy
- Neurological conditions impairing ventilator weaning
- Significant central nervous system disorders or comorbid conditions with over 50% six-month mortality
- Prisoners or persons unable to make decisions
- History of type 2 diabetes
- Atrial fibrillation or use of class III anti-arrhythmic drugs
- Left ventricle ejection fraction less than 40%
- Emergency condition at time of surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Colorado Denver | Anschutz Medical Campus
Denver, Colorado, United States, 80220-3706
Actively Recruiting
Research Team
T
Tobias Eckle, MD, PhD
CONTACT
N
Nick Naughton, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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