Actively Recruiting
A 12-week Randomized, Double-blind, Placebo-controlled Trial of Broccoli Sprout Extract to Improve Cognitive Function in Adults With Mild Cognitive Impairment
Led by Pusan National University Yangsan Hospital · Updated on 2026-01-13
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate whether broccoli sprout extract can improve cognitive function in adults aged 55 to 85 with mild cognitive impairment. The study also assesses the safety and possible side effects of taking this extract. Participants will be adults with mild cognitive issues but without dementia, capable of reading Korean, and meeting specific memory impairment criteria. Participants will be randomly assigned to receive either 1,000 mg of broccoli sprout extract or a placebo daily for 12 weeks. The study is double-blind, meaning neither the participants nor the researchers know who is receiving the extract or placebo. Clinic visits will occur at screening, week 0, week 6, and week 12 for health checks and cognitive testing. During the trial, researchers will evaluate changes in cognitive function using computerized neurocognitive tests, verbal learning, digit span, and auditory continuous performance tests, as well as the Korean Mini-Mental State Examination. Blood tests will measure brain-related proteins and oxidative stress markers. Participant safety will be monitored throughout, with the primary outcome measured at 12 weeks from the start.
CONDITIONS
Brief Title
Broccoli Sprout Extract for Cognitive Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 55 to 85 years, male or female
- Global Deterioration Scale score of 2 or 3 indicating subjective or mild objective memory impairment
- No diagnosis of dementia based on established criteria
- Ability to read Korean
You will not qualify if you...
- Severe medical conditions within past 6 months such as major stroke, cardiac disease, or cancer (stable cases may be included at investigator discretion)
- Diseases linked to cognitive impairment like dementia, Parkinson's disease, cerebral infarction
- Uncontrolled high blood pressure (160/100 mmHg or higher)
- Poor blood sugar control in diabetes (fasting glucose 160 mg/dL or higher)
- Uncontrolled thyroid problems under treatment
- Significant kidney or liver impairment
- Severe gastrointestinal symptoms
- Use of medications or supplements affecting cognition within past month
- Participation in other drug trials within past month or planned during this study
- Severe alcohol use disorder
- Allergies to study product ingredients
- Any other condition deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants take dietary broccoli sprout extract or a placebo daily to evaluate effects on cognitive function.
Clinic visits at 0, 6, and 12 weeks for checkups and tests
Trial Site Locations
Total: 1 location
1
Pusan National University Yangsan Hospital
Yangsan, South Korea, 50612
Actively Recruiting
Research Team
S
Sang Yeoup Lee, Professor, MD, PhD
Y
Ye Li Lee
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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