Actively Recruiting
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
Led by Assiut University · Updated on 2025-07-17
315
Participants Needed
1
Research Sites
172 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis requiring invasive mechanical ventilation. The primary outcome is a ranked composite of in-hospital mortality and time to ventilator liberation. Safety and procedural adverse events are closely monitored.
CONDITIONS
Official Title
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with bronchiectasis confirmed by high-resolution CT chest (HRCT)
- Patients with acute exacerbation of bronchiectasis who need antibiotic treatment at the hospital due to exacerbation
- Mechanically ventilated patients in the respiratory ICU
- Age 18 years or older
You will not qualify if you...
- Patients with active pulmonary tuberculosis
- Patients with allergic bronchopulmonary aspergillosis
- Patients who underwent interventional bronchoscopy for hemoptysis
- Age less than 18 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Assiut university hospitals
Asyut, Egypt, 71515
Actively Recruiting
Research Team
A
Ali A Ali, MSc
CONTACT
A
Ahmad M shaddad, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here