Actively Recruiting
Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema
Led by Mansoura University Hospital · Updated on 2025-05-29
30
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease (COPD), poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement. In recent years, bronchoscopic lung volume reduction (BLVR) has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema. BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents. Many techniques are available for BLVR as coil, endo-bronchial valve, and biological as thrombin, autologous blood and chemicals as silver nitrate solution.
CONDITIONS
Official Title
Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- COPD grade III or IV with localized (heterogeneous) emphysema confirmed by HRCT showing lung destruction >-950 Hounsfield units
- Respiratory symptoms despite optimal medical treatment
- Age less than 75 years
- Not a candidate for or refused lung volume reduction surgery
- Fit for fibro-optic bronchoscopy
- FEV1 less than 60% of predicted value
- Residual volume more than 100% of predicted value
- Total lung capacity more than 100% of predicted value
- Six-minute walk test distance less than 450 meters
You will not qualify if you...
- Significant co-morbidities limiting exercise or prognosis, including heart failure, arrhythmia, ischemic heart disease, and lung cancer
- Unfit for or refusal of fibro-optic bronchoscopy
- Homogeneous emphysema
- Age over 75 years
- Presence of lung fibrosis
- FEV1 greater than 60% of predicted value
- Current smoker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mohamed AbdElmoniem
Al Mansurah, Egypt, 35516
Actively Recruiting
Research Team
M
Mohamed AbdElmoniem
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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