Actively Recruiting
Brown Adipose Tissue Activity in Gilbert's Syndrome
Led by Medical University of Vienna · Updated on 2024-03-28
80
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
Sponsors
M
Medical University of Vienna
Lead Sponsor
U
University of Vienna
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this case-control study is to investigate energy metabolism and brown adipose tissue (BAT) activity in individuals with Gilbert's syndrome (GS) and controls. The main focus of the study is to analyze: 1. the link between bilirubin metabolism and metabolic health. 2. energy metabolism and body composition in individuals with Gilbert's syndrome and control subjects 3. brown adipose tissue activity in Gilbert's syndrome and healthy controls. Participants will undergo the following investigations: 1. cold exposure 2. PET-CT imaging with 18-F-FDG 3. MRI imaging of liver, abdominal fat and muscle 4. blood sampling 5. indirect calorimetry 6. bioelectrical impedance analysis 7. infrared thermography Researchers will compare individuals with GS and control subjects in terms of metabolic health, body composition and BAT activity.
CONDITIONS
Official Title
Brown Adipose Tissue Activity in Gilbert's Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Written consent to participate
- Liver markers (AST, ALT, GGT) less than twice the upper normal limit
- Non-smoker
- Moderate physical activity level
- Ability to understand study requirements
- For Gilbert's syndrome group: total bilirubin in blood above 1.2 mg/dL and unconjugated bilirubin above 1 mg/dL
- For control group: total bilirubin in blood 1.2 mg/dL or below and unconjugated bilirubin 1 mg/dL or below
You will not qualify if you...
- Age below 18 or above 65 years
- Current or past heart, lung, metabolic, or musculoskeletal disease
- Breastfeeding or pregnant
- Liver diseases including hepatitis A and B
- Kidney diseases
- Active tumor disease
- Organ transplant recipients
- Unwillingness to meet study demands
- Body weight not stable within ±5% for at least 3 months before study
- Any condition or behavior, including medication, posing personal risk or biasing results
- For Gilbert's syndrome group: total bilirubin in blood 1.2 mg/dL or below or unconjugated bilirubin 1 mg/dL or below
- For control group: total bilirubin in blood above 1.2 mg/dL or unconjugated bilirubin above 1 mg/dL
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
Research Team
K
Karl-Heinz Wagner, Univ.-Prof. Mag.
CONTACT
F
Florian Kiefer, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here