Study of Catheter Ablation Using High-Density Mapping for Treating Brugada Syndrome Patients with ECG Type 1 and 2 Patterns

What this Trial Is About

Researchers are studying Brugada Syndrome BrS, a heart condition that can cause dangerous irregular heartbeats, especially in patients who may not show symptoms at diagnosis. This study aims to evaluate the effectiveness of a catheter ablation procedure at medium to long-term follow-up in patients with BrS. The procedure targets abnormal heart signals detected using a high-density, high-resolution electrode array to better understand and treat the arrhythmogenic substrate associated with BrS. The study also investigates a new measurement called the dST-Tiso interval, which may predict the risk of arrhythmias in these patients. The treatment involves epicardial substrate homogenization by ablating abnormal fragmented prolonged low-frequency ventricular electrograms using a contact force catheter guided by detailed electrical mapping. This catheter ablation is performed in patients who have already had an implantable cardioverter defibrillator ICD and documented ventricular arrhythmias. The study collects data on heart electrical activity using advanced mapping tools and evaluates changes after the ablation procedure. The procedure aims to improve the definition of abnormal heart areas and may confirm links with specific ECG features. Participants will be monitored at 3, 6, and 12 months after the ablation procedure to assess freedom from ventricular arrhythmias. The study collects detailed electrical maps, vector data, and speed maps to help understand BrS mechanisms. Patients undergo regular follow-up visits where heart function and arrhythmia status are assessed. The study tracks long-term outcomes related to heart rhythm safety and effectiveness of the ablation approach. The total participation duration covers at least one year of follow-up after treatment.

Brugada Syndrome Substrate Characterization and Ablation