Actively Recruiting

Phase Not Applicable
Age: 11Years - 17Years
All Genders
Healthy Volunteers
NCT05701111

Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

Led by Stanford University · Updated on 2025-07-18

80800

Participants Needed

3

Research Sites

166 weeks

Total Duration

On this page

Sponsors

S

Stanford University

Lead Sponsor

P

Pure Edge Inc.

Collaborating Sponsor

AI-Summary

What this Trial Is About

In the last four years alone, residents of Puerto Rico have experienced a slew of natural disasters including Hurricane Maria in 2017, earthquakes in 2019 and 2020, the continued COVID-19 pandemic from 2020-2022, and most recently Hurricane Fiona. This series of distressing events can lead to an increased need for mental health resources and trauma treatment. Furthermore, the unique single-district structure of the Puerto Rican education system allows for the efficient dissemination of potential interventions and treatment to all students. The purpose of this study is to examine two treatment conditions for educators and school-aged children in Puerto Rico experiencing burnout, fatigue, and high stress: delivery of a mindfulness-based educator curriculum and, for children who report Post Traumatic Stress Disorder (PTSD) symptomatology, delivery of the mindfulness curriculum with the additional intervention of Cue-Centered Therapy (CCT). The study has two aims: 1) To assess the efficacy of the mindfulness curriculum and of CCT in a population of students, counselors, and teachers, characterized by high stress over the last few years of natural disasters and pandemic challenges and 2) To identify genetic contributions to resilience by analyzing gene expression in students before and after the intervention. The overarching goals of the investigators' research collaboration are to improve educators' psychological well-being and children's socioemotional development when faced with high stress and adversity and to improve mental health clinicians' competence and confidence in treating children exposed to trauma by training them in CCT. The investigators' research will identify critical biopsychosocial components responsible for the cognitive, behavioral, and emotional improvement and effective implementation strategies in a large but geographically dispersed school district. The knowledge base that will result from this study will inform the implementation of trauma-informed care in school settings and with populations experiencing stress and adversity, and contribute to the investigators' understanding of the underlying biology of these interventions to provide a rationale for further development and dissemination.

CONDITIONS

Official Title

Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

Who Can Participate

Age: 11Years - 17Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Teachers and students at a participating school site
  • Adults and students/caregivers willing to participate in the study
  • Youth aged 11-17 with exposure to at least one DSM-5-defined traumatic event and meeting posttraumatic symptom criteria per UCLA PTSD scale for Cue Centered Therapy
  • Willingness to participate in therapy for Cue Centered Therapy
  • Caregiver willing to participate in therapy for Cue Centered Therapy
  • Perpetrator of the traumatic event is not living in the home with the child for Cue Centered Therapy
Not Eligible

You will not qualify if you...

  • Students currently receiving trauma-focused interventions with a mental health professional
  • Low cognitive functioning (IQ less than 70)
  • Substance dependence as defined by DSM criteria
  • Autism or schizophrenia diagnosis
  • Clinically significant medical illness

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 3 locations

1

Stanford University

Palo Alto, California, United States, 94305

Not Yet Recruiting

2

Centros Sor Isolina Ferre

San Juan, Puerto Rico, Puerto Rico, 00926

Suspended

3

Department of Education Puerto Rico

San Juan, Puerto Rico

Actively Recruiting

Loading map...

Research Team

L

Lab Adminstrator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

5

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here