Actively Recruiting
His Bundle Pacing in Bradycardia and Heart Failure
Led by Yong-Mei Cha · Updated on 2025-12-24
80
Participants Needed
1
Research Sites
530 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Participants in this study will either have heart failure (HF) and are scheduled to undergo pace maker (PM) implantation, cardiac resynchronization therapy pacemaker (CRT-P), cardiac resynchronization therapy defibrillator (CRT-D) implantation, His bundle pacing (HIBP) or left bundle area pacing (LBAP) (including HIBP/LBAP for patients with HF, for patients who have failed CRT implant or patients who are CRT non-responders), or have atrioventricular (AV) block or bradycardia and are scheduled to undergo dual chamber pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and/or parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block. The hypothesis is that His bundle or parahisian pacing (HISP) and left bundle area pacing (LBAP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF).
CONDITIONS
Official Title
His Bundle Pacing in Bradycardia and Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically recommended to undergo pacemaker, cardiac resynchronization therapy pacemaker, cardiac resynchronization therapy defibrillator implantation, or His bundle/left bundle area pacing (including those with heart failure, failed CRT implant, or CRT non-responders)
- Any QRS duration
- Left ventricular ejection fraction 50% or less
- Recommended to undergo dual chamber pacemaker implantation for any atrioventricular block or sinus bradycardia
- Age 18 years or older
You will not qualify if you...
- Younger than 18 years
- Pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
Y
Yong-Mei Cha, M.D.
CONTACT
B
Brent W Quam
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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