Study of Breast and Colorectal Cancer Screening Navigation and Genetic Services for BlackAfrican American and Hispanic Women Aged 45 to 74

What this Trial Is About

This research aims to evaluate how bundled familial cancer risk assessment combined with navigation for multiple cancers colorectal and breast compares to navigation for breast cancer alone. The study also examines usual care referral to genetic services versus pretest education plus usual care referral. Researchers will study how effective bundled multicancer navigation is and for whom it works best through a detailed patient- and organization-level process evaluation across multiple sites. Participants are women referred for screening navigation who will receive either multicancer navigation or single breast cancer navigation, with a wait list control for colorectal cancer screening referral. Those eligible for genetic services will be randomized to receive combinations of multicancer or single cancer navigation paired with either usual care genetic referral or pretest education plus usual care referral. Navigation involves education, barrier assessment, scheduling, reminders, and documentation of screening completion. Participants not screened for colorectal cancer after six months in the single navigation arm will receive delayed colorectal cancer screening navigation. Women in the study will complete baseline assessments and be randomized to one of the study arms. Researchers will monitor receipt of colorectal and breast cancer screenings six months after navigation completion. Assessments include documentation of navigation steps and participant follow-up. The study plans to recruit 820 women, retaining 780 for analysis over two years. A mixed-methods process evaluation will be conducted alongside the trial to understand the implementation and effectiveness of the interventions.

Bundled Cancer Screening and Genetic Services Navigation