Actively Recruiting

Phase 2
Phase 3
Age: 19Years +
All Genders
NCT06456255

Bupivacaine and Epinephrine Injection Study

Led by Amin Javer · Updated on 2025-05-15

80

Participants Needed

1

Research Sites

32 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Endoscopic sinus surgery (ESS) is a common otolaryngologic procedure that aims to remove the partitions that separate the sinus cavities, remove inflamed tissue, and optimize the sinuses for topical medication use. In this procedure, the surgeon will inject a combination of drugs, local anesthetics, and vasoconstrictors, to reduce bleeding and improve visualization. However, previous studies have shown similar results when injected with only saline. In this study, investigators want to determine if the injection of local anesthesic+vasoconstrictor compared to no injection at all makes any difference in improving the surgeon's visualization during an ESS.

CONDITIONS

Official Title

Bupivacaine and Epinephrine Injection Study

Who Can Participate

Age: 19Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 19 years or older
  • Scheduled for primary endoscopic sinus surgery including septoplasty
Not Eligible

You will not qualify if you...

  • Cystic fibrosis
  • Systemic vasculitis or any bleeding disorders
  • Known or suspected hypersensitivity to bupivacaine or epinephrine
  • Previous sinus surgery
  • Inhaled drug use (e.g., cocaine) in the preceding 6 months
  • Nasal tumors
  • Patients on antiarrhythmics
  • History of severe liver illness
  • High-risk for complications during preoperative assessment (e.g., untreated hypertension, ischemic heart disease, cerebral vascular insufficiency, heart block, peripheral vascular disorder, uncontrolled hyperthyroidism, diabetes)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

St.Paul's Hospital Sinus Center

Vancouver, British Columbia, Canada, V6Z 1Y6

Actively Recruiting

Loading map...

Research Team

A

Amin Javer

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here