Effect of Bupivacaine and Epinephrine Injection Compared to No Injection During Endoscopic Sinus Surgery to Improve Surgical Visualization

What this Trial Is About

Endoscopic sinus surgery ESS is a common procedure to clear sinus cavities, remove inflamed tissue, and enhance sinus medication use. This trial evaluates whether injecting a combination of local anesthetic and vasoconstrictor during ESS improves the surgeons view compared to no injection. Previous studies indicated saline injections may have similar effects, so this study aims to clarify the benefit of the drug combination during surgery. Participants are randomly assigned to one of two groups one receives an injection of 0.25% bupivacaine with epinephrine, and the other undergoes a sham injection involving only a puncture without medication. The trial is double-blinded, so neither participants nor surgeons know which procedure is given. The study takes place during the one-day surgery visit. During the procedure, researchers assess bleeding using the Boezzart bleeding score along with total blood loss, surgical time, blood pressure, postoperative bleeding, and pain. These measures are recorded throughout the surgery day. The study aims to enroll adults aged 19 and older scheduled for primary ESS, with follow-up focused on surgical conditions and recovery outcomes.

Bupivacaine and Epinephrine Injection Study