Actively Recruiting
Comparison of Pain Relief by Bupivacaine With Dexmedetomidine and Bupivacaine Alone in Transversus Abdominis Plane Block for Postoperative Analgesia in Patients Undergoing Abdominal Surgeries
Led by Sheikh Zayed Medical College · Updated on 2025-12-22
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of adding dexmedetomidine to bupivacaine for pain relief after abdominal surgeries. This randomized controlled trial involves 80 patients aged 21 to 45 undergoing elective abdominal surgeries such as exploratory laparotomy, ileostomy reversal, cholecystectomy, or hernia repair. The study compares pain control and side effects between two groups to see if dexmedetomidine improves analgesia without increasing complications. Participants are randomly assigned to one of two groups. One group receives a combination of 0.25% bupivacaine and dexmedetomidine via an ultrasound-guided transversus abdominis plane (TAP) block at the end of surgery. The other group receives only 0.25% bupivacaine using the same TAP block method. Both groups are monitored for pain relief and other effects over 12 hours post-surgery. During the study, pain levels are measured using the Visual Analogue Scale (VAS) at multiple time points between 1 and 12 hours after surgery. Researchers also assess sedation using the Ramsay Sedation Scale and monitor vital signs like heart rate and blood pressure. Side effects such as hypotension, bradycardia, and nausea are recorded. Rescue pain medication is given if pain scores exceed 4. Data will be analyzed to determine if dexmedetomidine provides better pain control without increasing side effects.
CONDITIONS
Brief Title
Bupivacaine With or Without Dexmedetomidine for Postoperative Pain Relief in Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 21 to 45 years
- Undergoing elective abdominal surgery such as exploratory laparotomy, ileostomy reversal, laparoscopic or open cholecystectomy, or paraumbilical hernia mesh repair
- Ability to provide informed consent
You will not qualify if you...
- Pregnancy
- Severe allergies to local anesthetics
- Pre-existing chronic pain conditions
- Participation in another clinical trial within the last 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At surgery and up to 12 hours post-surgery
Participants receive an ultrasound-guided transversus abdominis plane (TAP) block with either a combination of bupivacaine and dexmedetomidine or bupivacaine alone for postoperative pain relief following abdominal surgery.
1 baseline visit (surgery) and several assessments up to 12 hours post-surgery
Trial Site Locations
Total: 1 location
1
Sheikh Zayed Medical College
Rahim Yar Khan, Punjab Province, Pakistan, 64200
Actively Recruiting
Research Team
R
Rameesha Musharaf, FCPS ANESTHESIA (PGR)
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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