Actively Recruiting
BurdEn of NEw Onset Atrial FIbrillation in patienTs With Acute Myocardial Infarction: the BENEFIT-AMI Multicenter Prospective Registry
Led by Shanghai 10th People's Hospital · Updated on 2026-03-19
774
Participants Needed
5
Research Sites
26 weeks
Total Duration
On this page
Sponsors
S
Shanghai 10th People's Hospital
Lead Sponsor
S
Shanghai Tong Ren Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the importance of the burden of new-onset atrial fibrillation (NOAF) in patients who develop this condition during acute myocardial infarction (AMI) hospitalization. This study aims to confirm earlier findings that a higher NOAF burden leads to worse outcomes and to understand factors that contribute to increasing NOAF burden after a heart attack. The study also seeks to create a prediction model to help assess risk and to explore how NOAF burden can guide blood-thinning treatment decisions in these patients. Patients admitted for AMI who develop NOAF during hospitalization will be included. Participants will have continuous electronic monitoring (CEM) for at least 5 days to measure NOAF burden, calculated as the total duration of atrial fibrillation divided by the total monitoring time. Patients will be divided into low or high NOAF burden groups based on a previously established threshold of 10.87%. This multicenter registry involves data collection from multiple hospitals and includes demographic information, heart health factors, lab tests, and imaging results to fully characterize participants. After discharge, all patients who survive will be followed for at least 2 years to record cardiovascular outcomes such as death, heart failure hospitalizations, recurrent heart attacks, strokes, and major bleeding events. The primary outcome is all-cause death within one year. The study uses continuous heart rhythm monitoring during hospitalization and gathers detailed clinical information to understand the impact of NOAF burden and its role in guiding treatment. Participation involves data collection during hospital stay and long-term follow-up visits to assess health outcomes.
CONDITIONS
Brief Title
BurdEn of NEw Onset Atrial FIbrillation in patienTs With Acute Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (>18 years old)
- Patients with acute myocardial infarction (including STEMI and NSTEMI) who developed new-onset atrial fibrillation during the hospital stay
- Patients must have received continuous electronic monitoring for at least 5 days during hospitalization
- Patients must provide informed consent
You will not qualify if you...
- Patients with a history of atrial fibrillation before the current myocardial infarction
- Patients with rheumatic valvular disease
- Patients with sick sinus syndrome
- Patients undergoing emergency coronary artery bypass surgery
- Patients with malignant tumors expected to live less than 1 year
- Patients who refuse continuous electronic monitoring or whose heart rhythm data cannot be collected
- Patients who refuse or have contraindications for percutaneous coronary intervention (PCI)
- Patients who died during the hospital stay
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
During hospitalization
Duration - At least 5 days
Participants receive continuous electronic monitoring for at least 5 days during hospitalization to evaluate new-onset atrial fibrillation burden.
Continuous monitoring during hospital stay
Duration - At least 2 years
Participants discharged alive are followed for at least 2 years to record cardiovascular outcomes such as death, heart failure hospitalization, recurrent myocardial infarction, ischemic stroke, and major bleeding.
Follow-up visits during the 2-year period
Trial Site Locations
Total: 5 locations
1
Kaifeng Central Hospital
Kaifeng, Henan, China
Actively Recruiting
2
Luoyang Central Hospital
Luoyang, Henan, China
Actively Recruiting
3
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
4
Department of Cardiology, Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China, 200072
Actively Recruiting
5
Shanghai Seventh People's Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
Research Team
J
Jiachen Luo, M.D., Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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