Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT05851391

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

Led by University of California, San Francisco · Updated on 2025-05-15

30

Participants Needed

1

Research Sites

194 weeks

Total Duration

On this page

Sponsors

U

University of California, San Francisco

Lead Sponsor

T

The ZOLL Foundation

Collaborating Sponsor

AI-Summary

What this Trial Is About

RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

CONDITIONS

Official Title

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Non-traumatic, out-of-hospital cardiac arrest
  • Comatose on admission, defined as not following commands
  • Return of spontaneous circulation within less than 45 minutes
  • Admission to the intensive care unit
  • Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous EEG monitoring within 7 days from return of spontaneous circulation
Not Eligible

You will not qualify if you...

  • Acute cerebral hemorrhage or infarction
  • Pregnancy
  • Prisoners

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Zuckerberg San Francisco General Hospital

San Francisco, California, United States, 94110

Actively Recruiting

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Research Team

E

Edilberto Amorim, MD

CONTACT

K

Kevin Bao

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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