Actively Recruiting
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study
Led by Bin Cai · Updated on 2023-09-28
1000
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective multicenter observational study to understand the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders. The study aims to assess the clinical, genetic, and epigenetic characteristics of patients with CADASIL to help improve clinical management of the condition. Participants include CADASIL patients confirmed by genetic test or skin biopsy, asymptomatic carriers of the NOTCH3 mutation, relatives of affected individuals, and unrelated healthy controls. There are no drug or treatment interventions as this is an observational study focused on gathering data over time. Participants will be followed from enrollment until death or up to 20 years, during which researchers will collect clinical information, genetic data, and imaging results. The primary outcome is overall outcomes in CADASIL patients over this period, while secondary outcomes include correlations between genetic findings and clinical features. Assessments will be conducted periodically as part of routine clinical evaluations.
CONDITIONS
Brief Title
CADASIL Registry Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Age over 18 years
- Clinical diagnosis of CADASIL confirmed by genetic test or skin biopsy
- Asymptomatic carriers of the NOTCH3 mutation
- Relatives of CADASIL patients or carriers
- Unrelated healthy controls
You will not qualify if you...
- Unable to cooperate with study assessments
- Serious systemic illness such as heart, liver, kidney disease, or major mental illness
- Contraindications for imaging examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 20 years
Participants are observed for overall outcomes and correlation of genotype and phenotype over an extended period.
Visits scheduled as needed for assessments
Trial Site Locations
Total: 1 location
1
Department of Neurology , First Affiliated Hospital Fujian Medical University
Fuzhou, Fujian, China, 350004
Actively Recruiting
Research Team
L
Lin Yi, PhD
C
Cai Bin, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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