Actively Recruiting
CAIX PET/ CT Guided Radiation Therapy in CcRCC.
Led by Peking University First Hospital · Updated on 2026-04-20
70
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, single-arm study in adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and undergo dual PET/CT imaging (FDG PET/CT and a CAIX-targeted PET/CT) to map disease sites. When feasible, PET/CT-visible lesions will be treated with image-guided stereotactic ablative radiotherapy (SABR). Patients will be followed to evaluate progression-free survival, local control of treated lesions, and treatment-related adverse events (planned enrollment: \~70).
CONDITIONS
Official Title
CAIX PET/ CT Guided Radiation Therapy in CcRCC.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Histologically confirmed clear cell renal cell carcinoma
- Recurrent or metastatic disease
- Planned or ongoing first-line systemic therapy with targeted therapy plus anti-PD-1 immunotherapy
- Availability of dual PET/CT imaging (FDG PET/CT and CAIX-targeted PET/CT) and eligibility for radiotherapy planning
- Multidisciplinary assessment confirms feasibility to treat at least 75% of detectable lesions with radiotherapy
- Able to provide written informed consent
You will not qualify if you...
- Unable to receive stereotactic radiotherapy as planned
- Presence of uncontrolled serious comorbidities or active infection
- Pregnant or breastfeeding
- Unable or unwilling to comply with study procedures and follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
M
Mingwei Ma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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