Actively Recruiting
Calcium Replacement Therapy in Postoperative Hypoparathyroidism
Led by Tartu University Hospital · Updated on 2026-05-11
50
Participants Needed
2
Research Sites
158 weeks
Total Duration
On this page
Sponsors
T
Tartu University Hospital
Lead Sponsor
E
East Tallinn Central Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether a lower-dose calcium replacement therapy is non-inferior to a higher-dose regimen in preventing symptomatic hypoparathyroidism in patients following thyroidectomy. The hypothesis is: • lower-dose calcium replacement therapy is non-inferior to higher-dose therapy in preventing symptomatic hypoparathyroidism during the first two postoperative weeks Researchers will compare patients receiving a lower-dose calcium replacement regimen with those receiving a higher-dose regimen to assess whether the lower dose is not associated with a higher incidence of symptomatic hypoparathyroidism. Patients who develop post-thyroidectomy hypoparathyroidism are divided into groups for calcium replacement therapy. If they are asymptomatic, they will be scheduled for a follow-up visit at two weeks after surgery. During the follow-up visit, calcium metabolism will be evaluated, and treatment adjusted if necessary.
CONDITIONS
Official Title
Calcium Replacement Therapy in Postoperative Hypoparathyroidism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old who had surgery involving both lobes of the thyroid gland (thyroidectomy, near-total thyroidectomy, subtotal thyroidectomy, or completed thyroidectomy)
- Post-operative day one parathyroid hormone (PTH) levels below normal range but not below 1.06 pmol/L, not requiring calcium replacement with calcitriol (rocaltrol)
You will not qualify if you...
- Previously diagnosed osteoporosis or taking calcium and vitamin D supplements before thyroid surgery
- Renal insufficiency with eGFR less than 30
- Concomitant hyperparathyroidism requiring simultaneous thyroidectomy and parathyroidectomy for parathyroid adenoma
AI-Screening
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Trial Site Locations
Total: 2 locations
1
East Tallinn Central Hospital
Tallinn, Other, Estonia, 11914
Actively Recruiting
2
Tartu University Hospital
Tartu, Estonia
Actively Recruiting
Research Team
H
Hanna Hollman
CONTACT
C
Ceith Nikkolo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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