Actively Recruiting
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
Led by Jason Sperry · Updated on 2026-04-14
1050
Participants Needed
14
Research Sites
191 weeks
Total Duration
On this page
Sponsors
J
Jason Sperry
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.
CONDITIONS
Official Title
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 90 years
- Injured patients at risk of hemorrhagic shock with systolic blood pressure 60 90mmHg and heart rate 68 108 at scene, outside hospital, or during transport
- OR systolic blood pressure 60 70mmHg at scene, outside hospital, or during transport
- Blood or blood component transfusion started before hospital arrival or expected within 60 minutes of arrival
- Clinical indication for major hemorrhage control surgery within 60 minutes of hospital arrival
- Anticipated admission to the intensive care unit
You will not qualify if you...
- Wearing a CAVALIER opt-out bracelet
- Age under 18 or over 90 years
- Injury caused by a simple fall from standing height
- Known prisoner status
- Known pregnancy
- Traumatic arrest with more than 5 minutes of CPR without return of vital signs
- Exposed brain matter or penetrating brain injury
- Injuries caused by drowning or hanging alone
- Objection to study participation by patient or family at scene or trauma center
- Inability to obtain intravenous or intraosseous access (pre-hospital phase) or intravenous access (in-hospital phase)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
2
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Actively Recruiting
3
Zuckerberg San Francisco General Hospital and Trauma Center at University of California, San Francisco
San Francisco, California, United States, 94110
Actively Recruiting
4
Denver Health Medical Center
Denver, Colorado, United States, 80204
Actively Recruiting
5
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
6
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
7
University of Missouri Health Care
Columbia, Missouri, United States, 65202
Actively Recruiting
8
University of New Mexico
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
9
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
10
Mount Carmel East Hospital
Columbus, Ohio, United States, 43213
Actively Recruiting
11
Allegheny Health Network
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
12
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
13
Texas Tech University Health Sciences Center
Lubbock, Texas, United States, 79430
Actively Recruiting
14
University of Washington Harborview Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
Research Team
J
Jason Sperry, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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