Actively Recruiting
CAlgary SAlt for POTS
Led by University of Calgary · Updated on 2026-05-07
50
Participants Needed
1
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend \~10 g of salt and 2-3 L of fluid per day. Despite this recommendation, there is no long term data evaluating the use of salt in POTS. This randomized, placebo-controlled cross-over trial will evaluate a high salt diet, compared to a normal salt diet over a period of 3 months. Participants will complete 3 in lab evaluations including autonomic function testing, tilt table testing, blood volume and urine sodium evaluation, plasma catecholamine measurements and and cytokine measurements.
CONDITIONS
Official Title
CAlgary SAlt for POTS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician diagnosis of POTS as defined by the CCS Consensus Statement
- Sustained excessive orthostatic tachycardia of 30 bpm or more within 10 minutes of standing
- No orthostatic hypotension (no blood pressure drop >20/10 mmHg in 3 minutes of standing)
- Chronic orthostatic symptoms that improve when lying down
- Age between 18 and 60 years old
- Ability to attend the Calgary Autonomic Research Clinic in Calgary
- Resident of Canada
You will not qualify if you...
- Known cause of postural tachycardia such as acute dehydration or thyroid disease
- Presence of somatization or severe anxiety symptoms
- Pregnant women (self-reported)
- Underlying causes of tachycardia including acute hypovolemia, endocrinopathy, anemia, anxiety, medication or recreational drug effects, and prolonged bedrest
- Any factor judged by the investigator to prevent study completion, including poor compliance in past studies
- Use of fludrocortisone due to its effects on kidney salt handling
- Receipt of intravenous saline in the two months before or planned during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
Research Team
S
Satish R Raj, MD MSCI
CONTACT
T
Tanya Siddiqui, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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