CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome Study

What this Trial Is About

Postural Orthostatic Tachycardia Syndrome (POTS) is a condition that often causes disabling symptoms and is linked to low blood volume. Researchers are evaluating the effects of a high salt diet compared to a normal salt diet over three months to see if adding salt helps reduce heart rate and improve symptoms. This randomized, placebo-controlled cross-over study aims to understand whether increased salt intake can sustain improved blood volume and reduce symptoms in POTS over a longer period. Participants will follow a moderate salt diet while receiving either additional salt capsules or placebo capsules for six weeks each, switching between treatments in a cross-over design. Salt capsules contain 6 grams of slow-release sodium chloride, taken as 2 grams three times daily. The placebo capsules contain microcrystalline cellulose. Participants will receive three in-lab visits including baseline assessment and evaluations after each diet period, along with urine sodium tests and online surveys. Throughout the study, participants will undergo autonomic function testing including a 10-minute tilt test, blood volume measurements, and blood sample collections with an IV. They will provide 24-hour urine samples to assess salt intake compliance. Researchers will measure heart rate, symptom scores, blood pressure, stroke volume, and plasma catecholamines. Surveys on symptoms and patient experience will be collected. The study involves regular monitoring over the three-month period to assess the effects of salt intake on POTS symptoms and cardiovascular responses.

CAlgary SAlt for POTS