Actively Recruiting
CALM Study: Can A Prebiotic Fibre bLend Improve Stress, Mood, and Anxiety?
Led by Myota GmbH · Updated on 2026-03-13
156
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
Sponsors
M
Myota GmbH
Lead Sponsor
U
University of Reading
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial will investigate whether a powdered prebiotic fibre blend can improve perceived stress levels in healthy adults with mild-severe stress levels.
CONDITIONS
Official Title
CALM Study: Can A Prebiotic Fibre bLend Improve Stress, Mood, and Anxiety?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-50 years of age
- Capacity to give informed consent to participate in the study
- Able to comply with study requirements and visits
- Meet the range required for mild-severe stress levels (as assessed by DASS-42 stress subscale)
- Normal or corrected to normal vision and/or hearing
You will not qualify if you...
- Current smoker
- Having food allergies and/or intolerances
- Diagnosis of Type 1 or 2 diabetes or cardiovascular disease or psychiatric or neurological conditions (e.g. schizophrenia, dementia) including eating disorders
- Current or previous diagnosis of depression in past 6 months
- Receiving medications that lower cholesterol, blood pressure, blood glucose levels, or improve insulin sensitivity
- Receiving antidepressant or anti-anxiety medications or treatments
- Receiving hormonal birth control
- Perimenopause or menopause
- Pregnancy, lactation, or an intent to become pregnant during the course of the study
- Continuous antibiotic use for > 3 days within 1 month prior to enrolment
- Continuous use of weight-loss drug for > 1 month before screening
- Major change in dietary intake in past month (e.g. excluding whole food groups)
- Currently consuming daily prebiotic or probiotic supplements
- Prior use (< 6 months) of any blood glucose or cholesterol lowering medication
- Any significant GI condition affecting GI absorption including (but not limited to) inflammatory bowel disease, weight loss surgery, irritable bowel disease.
- End stage renal disease
- Active cancer, or treatment for any cancer, in last 3 years
- Consuming more than 20g of fibre a day as assessed by the 18-item FiberScreen
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CALM Study Site
London, United Kingdom, EC2A 4BQ
Actively Recruiting
Research Team
C
Caitlin Hall, PhD, RD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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