Actively Recruiting
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
Led by Washington University School of Medicine · Updated on 2026-03-25
220
Participants Needed
28
Research Sites
1565 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
S
St. Louis Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.
CONDITIONS
Official Title
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient must have a non-malignant disorder, excluding thalassemia for Stratum 1
- Patient must have thalassemia receiving 8/8 HLA-matched bone marrow or 5-8/8 HLA-matched umbilical cord blood for Stratum 2
- Patient must have a hemoglobinopathy receiving 7/8 HLA-matched bone marrow or 5-8/8 HLA-matched umbilical cord blood for Stratum 3
- Patient must have a non-malignant disorder (excluding hemoglobinopathy) receiving 7/8 HLA-matched bone marrow or 5-8/8 HLA-matched umbilical cord blood for Stratum 4
- Recipient age under 21 years
- Lansky or Karnofsky performance score of 40 or higher
- Adequate lung, kidney, liver, and other organ function as defined in the protocol
- Negative pregnancy test
- Adequate total nucleated cell or CD34+ stem cell dose as defined in the protocol
- If the patient has sickle cell disease, Hemoglobin S level must be less than 30%
You will not qualify if you...
- HIV positive
- Active invasive infection
- Pregnancy or currently breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
2
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
3
University of California
San Diego, California, United States, 92123
Actively Recruiting
4
Yale School of Medicine
New Haven, Connecticut, United States, 06510
Actively Recruiting
5
George Washington University School of Medicine
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
6
Nemours Children's Health
Jacksonville, Florida, United States, 32207
Completed
7
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
8
Miami Children's Hospital
Miami, Florida, United States, 33155
Completed
9
All Children's Hospital
St. Petersburg, Florida, United States, 33701
Completed
10
Children's Memorial Hospital
Chicago, Illinois, United States, 60614
Completed
11
Indiana University School of Medicine
Indianapolis, Indiana, United States, 46202
Actively Recruiting
12
Children's Hospital of New Orleans
New Orleans, Louisiana, United States, 70118
Completed
13
Children's Mercy
Kansas City, Missouri, United States, 64108
Completed
14
St. Louis University
St Louis, Missouri, United States, 63104
Actively Recruiting
15
Washington University School of Medicine (in St. Louis)
St Louis, Missouri, United States, 63110
Actively Recruiting
16
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Completed
17
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
18
University of North Carolina
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
19
Carolinas Medical Center
Charlotte, North Carolina, United States, 28232
Completed
20
Duke Children's Hospital
Durham, North Carolina, United States, 27705
Completed
21
The University of Oklahoma
Oklahoma City, Oklahoma, United States, 73104
Completed
22
University of Pittsburg
Pittsburgh, Pennsylvania, United States, 15224
Completed
23
Cook Children's Hospital
Forth Worth, Texas, United States, 76104
Completed
24
Texas Transplant Institute
San Antonio, Texas, United States, 78229
Completed
25
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
26
BC Children's Hospital
Vancouver, British Columbia, Canada, V6H 3N1
Completed
27
University of Manitoba
Winnipeg, Manitoba, Canada, MB R3E 0T4
Completed
28
University of Calgary
Calgary, Canada
Completed
Research Team
L
Lissy Keller, CCRP
CONTACT
I
Ian Snyder, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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