Actively Recruiting
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Led by Sunnybrook Health Sciences Centre · Updated on 2026-04-28
754
Participants Needed
43
Research Sites
336 weeks
Total Duration
On this page
Sponsors
S
Sunnybrook Health Sciences Centre
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether CABG compared to PCI is associated with a reduction in all-cause death, stroke, spontaneous myocardial infarction (MI), urgent repeat revascularization (RR), or heart failure (HF) readmission over a median follow-up of 5 years in patients with multivessel/LM CAD and ischemic left ventricular dysfunction (iLVSD). Eligible patients are considered by the local Heart Team appropriate and amenable for non-emergent revascularization by both modes of revascularization. The secondary objectives are to describe the early risks of both procedures, and a comprehensive set of patient-reported outcomes longitudinally.
CONDITIONS
Official Title
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Left ventricular ejection fraction (LVEF) of 40% or less measured within 2 months before randomization
- Presence of important multivessel coronary artery disease (triple vessel or double vessel including left anterior descending or left main artery) with significant stenosis as defined by angiography or functional measurements
- Agreement by the local Heart Team that guideline-directed medical therapy has been started for at least 1 month or started before randomization in hospitalized patients
- Signed informed consent
You will not qualify if you...
- Decompensated heart failure requiring inotropic support, ventilation, or mechanical cardiac support within 48 hours before randomization
- Recent ST-elevation myocardial infarction within 4 weeks
- Severe valvular disease or other conditions requiring additional surgical repair
- Planned major surgical procedures other than permitted atrial appendage occlusion or atrial fibrillation ablation
- Prior PCI within the past 12 months
- Prior cardiac surgery
- High bleeding risk preventing use of dual antiplatelet therapy
- Conditions likely to cause poor treatment adherence
- Severe end-organ failure reducing life expectancy to less than 5 years
- Current pregnancy
- Patient not suitable for both CABG and PCI according to Heart Team
- Diagnosis of Takotsubo Cardiomyopathy (Broken Heart Syndrome)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 43 locations
1
Cedars-Sinai
Los Angeles, California, United States, 90048
Actively Recruiting
2
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
3
UofL Health, Inc
Louisville, Kentucky, United States, 40202
Actively Recruiting
4
John Hopkins Hospital
Baltimore, Maryland, United States, 21205
Actively Recruiting
5
Mayo Clinic
Rochester, Minnesota, United States, 55905
Withdrawn
6
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
7
Medical University of Vienna
Vienna, Austria
Active, Not Recruiting
8
Heart Institute, Medical School of the University of Sao Paulo_INCOR
São Paulo, Brazil, 05403-900
Actively Recruiting
9
University of Calgary; Libin Cardiovascular Institute
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
10
Mackenzie Health Sciences Center
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
11
Fraser Health; Royal Columbian Hospital
New Westminster, British Columbia, Canada, V3L3W7
Withdrawn
12
Providence Health
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
13
The University of Manitoba and St. Boniface Hospital Inc.
Winnipeg, Manitoba, Canada, R2H 2A6
Actively Recruiting
14
Queen Elizabeth II Hospital
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
15
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
16
London Health Sciences Center, University Hospital
London, Ontario, Canada, N6A 5A5
Actively Recruiting
17
Southlake Regional HC
Newmarket, Ontario, Canada, L3Y 2P9
Actively Recruiting
18
Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
19
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
20
St. Michael's
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
21
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
22
Center Hospitalier Universitaire de Montreal
Montreal, Quebec, Canada, , H2X OC1
Actively Recruiting
23
Montreal Heart Institute
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
24
Hospital Sacre-Coeur
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
25
Institut de Cardiologie Quebec (QC) - Laval
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
26
Jilin Heart Hospital
Jilin, Changchun, China, 130117
Actively Recruiting
27
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200031
Actively Recruiting
28
Clinical Hospital Dubrava
Sušak, Zagreb, Croatia, 10000
Actively Recruiting
29
Al Nas Hospital
Cairo, Qalyubia Governorate, Egypt
Actively Recruiting
30
University Hospital Dusseldorf
Düsseldorf, Germany, 40225
Actively Recruiting
31
Leipzig Heart Center
Leipzig, Germany, 04289
Actively Recruiting
32
G Kuppuswamy Naidu Memorial Hospital (GKNM)
Palayam, Tamil Nadu, India, 641037
Actively Recruiting
33
European Hospital, Via Portuense
Roma, RM, Italy, 00149
Actively Recruiting
34
Instituto Mexicano del Seguro Social (IMSS)
Mexico City, Mexico
Actively Recruiting
35
Medical University Bialystok
Bialystok, Poland, 15-089
Actively Recruiting
36
Medical University of Silesia
Katowice, Poland
Active, Not Recruiting
37
Unidade Local de Saude Lisboa Ocidental (ULSLO)
Lisbon, Portugal, 1350-410
Actively Recruiting
38
Centro Hospitalar e Universitário Sao João
Porto, Portugal, 4200-319
Actively Recruiting
39
Dedinje Cardiovascular Institute
Belgrade, Serbia
Actively Recruiting
40
Hospital Clinic de Barcelona (ICCV)
Barcelona, L'Eixample, Spain, 08036
Actively Recruiting
41
Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, Spain, 30120
Actively Recruiting
42
Hospital del Vinalopó
Alicante, Spain
Actively Recruiting
43
Hospital Universitario de Navarra
Pamplona, Spain, 31008
Actively Recruiting
Research Team
S
Stephen Fremes, MD,MSc,FRCSC
CONTACT
R
Reena Karkhanis, MBBS,DA,MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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