Actively Recruiting
CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
Led by University Health Network, Toronto · Updated on 2025-12-03
5500
Participants Needed
27
Research Sites
515 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
T
Takeda Canada, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will collect data on Canadian cancer patients that have uncommon/rare changes in their tumours, such as alterations/rearrangements in the genetic material inside cells - known as deoxyribonucleic acid, or DNA, which acts as a map and gives directions to the cells on how to make other substances the body needs - because some of these changes have been found to respond to different drugs that help to stop the cancer. These rare changes occur in genes such as but not limited to ALK, EGFR, ROS1, BRAF, and NTRK which have targeted drugs in a family known as tyrosine kinase inhibitors (TKIs), and KRAS G12C mutation, which now has a targeted inhibitor drug therapy for patients with non small cell lung cancer (NSCLC). The goals for the study are to compare the natural history of such cancers and the treatment outcomes, including toxicities and patient-reported outcomes, for the different therapies.
CONDITIONS
Official Title
CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older at cancer diagnosis
- Diagnosed with malignant tumors that have rare molecular alterations identified by molecular testing
- Molecular testing reports available to confirm types of molecular alterations from PCR-based next generation sequencing, immunohistochemistry, fluorescence in situ hybridization, or liquid biopsy
- Canadian resident receiving or planning to receive follow-up cancer care in Canada at enrollment
You will not qualify if you...
- Patient or deceased patient previously refused to enroll or is unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
Tom Baker Cancer Centre - University of Calgary - Alberta Health Services
Calgary, Alberta, Canada
Actively Recruiting
2
Cross Cancer Institute, University of Alberta - Alberta Health Services
Edmonton, Alberta, Canada
Not Yet Recruiting
3
BC Cancer
Vancouver, British Columbia, Canada
Actively Recruiting
4
CancerCare Manitoba/University of Manitoba
Winnipeg, Manitoba, Canada
Actively Recruiting
5
Dr. Everett Chalmers Regional Hospital
Fredericton, New Brunswick, Canada
Actively Recruiting
6
Dr. H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, Canada
Not Yet Recruiting
7
Queen Elizabeth II (QEII) Health Sciences Centre
Halifax, Nova Scotia, Canada
Actively Recruiting
8
William Osler Health System - Brampton Civic Hospital
Brampton, Ontario, Canada
Actively Recruiting
9
Health Sciences North
Greater Sudbury, Ontario, Canada
Actively Recruiting
10
Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton, Ontario, Canada
Actively Recruiting
11
Kingston Health Sciences Centre (KHSC)
Kingston, Ontario, Canada
Actively Recruiting
12
Lawson Health Research Institute - London Health Sciences Centre
London, Ontario, Canada
Actively Recruiting
13
Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
Actively Recruiting
14
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Ontario, Canada
Not Yet Recruiting
15
Princess Margaret Cancer Centre (PMCC) - University Health Network (UHN)
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
16
Mount Sinai Hospital
Toronto, Ontario, Canada
Actively Recruiting
17
Sunnybrook Research Institute - Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Actively Recruiting
18
Centre hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada
Actively Recruiting
19
Hôpital du Sacré-Coeur-de-Montréal (HSCM)
Montreal, Quebec, Canada
Actively Recruiting
20
Jewish General Hospital
Montreal, Quebec, Canada
Actively Recruiting
21
McGill University Health Centre
Montreal, Quebec, Canada
Not Yet Recruiting
22
St. Mary's Hospital Center
Montreal, Quebec, Canada
Not Yet Recruiting
23
Centre hospitalier de l'université de Québec - Université Laval
Québec, Quebec, Canada
Not Yet Recruiting
24
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Quebec, Canada
Not Yet Recruiting
25
Centre hospitalier universitaire de Sherbrooke (CHUS)
Sherbrooke, Quebec, Canada
Actively Recruiting
26
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
Not Yet Recruiting
27
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Not Yet Recruiting
Research Team
F
Faisal Al-Agha, BSc
CONTACT
R
Roula Raptis, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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