Actively Recruiting
Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Led by McMaster University · Updated on 2026-01-07
240
Participants Needed
6
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the role of airway mucus blockages in three common lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. These conditions affect many people and cause symptoms like coughing, breathlessness, and wheezing. The study aims to better understand mucus plugging by comparing individuals with these diseases to healthy volunteers, using advanced imaging and clinical tests. The goal is to find ways to better identify and treat mucus-related problems and share this knowledge with patients and healthcare providers across Canada. The study is observational and will follow adults in different disease groups as well as healthy controls over a 24-month period. Participants will undergo clinical and research assessments including chest CT scans to visualize mucus, sputum analyses, breathing tests, quality of life questionnaires, and cough monitoring. Testing will be done twice, two years apart, to observe changes over time. The study involves regular check-ins, including telemonitoring visits every three months to track participants' health status. Participants will be involved in several visits including screening, baseline assessment, periodic telemonitoring, and a final evaluation at the end of the monitoring period. Researchers will collect data on mucus scores from CT scans at the start and after 48 months, along with other clinical and quality of life measures. This comprehensive approach helps monitor disease progression, mucus persistence, and related biomarkers. The study lasts over several years, allowing long-term observation of mucus effects in lung diseases and healthy individuals.
CONDITIONS
Brief Title
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18 years old or older
- Asthma group: Confirmed diagnosis of moderate-to-severe asthma by a respiratory physician with objective evidence or specialist confirmation
- COPD group: Confirmed moderate-to-severe COPD by a respiratory physician according to GOLD criteria, with specific lung function and symptom scores
- Chronic cough group: Refractory or unexplained chronic cough lasting over 1 year with normal chest X-ray and no airflow obstruction
- Healthy controls: No history of respiratory disease or lung disorders, no inhaled medication or corticosteroid use, normal lung function and low dyspnea scale score
You will not qualify if you...
- Pregnant or breastfeeding
- Current smoker, smoked within last 6 months, or more than 10 years pack smoking history
- Recent exacerbation within 4 weeks before recruitment
- History of preterm birth before 36 weeks gestation or perinatal complications
- Other pulmonary disorders besides study conditions
- Suspected primary ciliary dyskinesia
- Current use of mucolytic medications
- Memory, cognitive, or psychiatric issues that prevent participation
- Recent treatment with biologic therapies within specified timeframes before study start
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 months
Participants are observed with quarterly telemonitoring visits to track their health status over time.
Quarterly visits (remote)
Duration - 1 day
Participants undergo an assessment at the end of the monitoring period to evaluate outcomes.
1 visit (in-person)
Trial Site Locations
Total: 6 locations
1
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Not Yet Recruiting
2
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
3
Robarts Research Institute
London, Ontario, Canada, N6A 5B7
Not Yet Recruiting
4
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Not Yet Recruiting
5
Quebec Heart and Lung Institute - Laval University
Québec, Quebec, Canada, G1V 4G5
Not Yet Recruiting
6
Université de Sherbrooke
Sherbrooke, Quebec, Canada, J1H 5N4
Not Yet Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here