Canadian Consortium Study on Airway Mucus in Asthma, COPD, and Chronic Cough Observational Research on Mucus Impact and Biomarkers in Adults

What this Trial Is About

Researchers are studying the role of airway mucus blockages in three common lung diseases asthma, chronic obstructive pulmonary disease COPD, and chronic cough. These conditions affect many people and cause symptoms like coughing, breathlessness, and wheezing. The study aims to better understand mucus plugging by comparing individuals with these diseases to healthy volunteers, using advanced imaging and clinical tests. The goal is to find ways to better identify and treat mucus-related problems and share this knowledge with patients and healthcare providers across Canada. The study is observational and will follow adults in different disease groups as well as healthy controls over a 24-month period. Participants will undergo clinical and research assessments including chest CT scans to visualize mucus, sputum analyses, breathing tests, quality of life questionnaires, and cough monitoring. Testing will be done twice, two years apart, to observe changes over time. The study involves regular check-ins, including telemonitoring visits every three months to track participants health status. Participants will be involved in several visits including screening, baseline assessment, periodic telemonitoring, and a final evaluation at the end of the monitoring period. Researchers will collect data on mucus scores from CT scans at the start and after 48 months, along with other clinical and quality of life measures. This comprehensive approach helps monitor disease progression, mucus persistence, and related biomarkers. The study lasts over several years, allowing long-term observation of mucus effects in lung diseases and healthy individuals.

Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough