Canadian Critical Care Trial Evaluating Vasopressors, Platelet Transfusions, and Nutrition Support in ICU Patients

What this Trial Is About

This research evaluates common supportive care treatments used in intensive care units ICUs worldwide, focusing on vasopressors, platelet transfusions, and nutrition. It is an international, multi-center, randomized, adaptive platform trial studying how these interventions are used for critically ill patients, particularly those in states like cardiovascular shock or with thrombocytopenia. The study aims to improve the understanding of these therapies, which are widely used but not well supported by strong scientific evidence. Participants are assigned to different groups based on the intervention being studied. In the vasopressor domain, patients receive vasoactive medications with blood pressure targets set in four different ranges. The platelet domain randomizes ICU patients with low platelet counts to different thresholds for receiving platelet transfusions before procedures. The nutrition domain compares feeding patients either by boluses three times a day or continuous feeding over 24 hours. Each domain follows specific protocols to evaluate these approaches during ICU care. Throughout the study, participants undergo various assessments including monitoring mortality rates, organ dysfunction, bleeding outcomes, and quality of life. Data is collected at hospital discharge, up to 30 or 90 days, and for one year in some cases. The study measures include recruitment rates and clinical outcomes relevant to each domain. The trial will run from 2025 to 2030, with ongoing evaluations to guide supportive care in critical illness.

Canadian Critical Care Comparative Effectiveness Platform