Actively Recruiting
Canadian Critical Care Comparative Effectiveness Platform
Led by Université de Sherbrooke · Updated on 2026-03-27
5500
Participants Needed
8
Research Sites
275 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial. CEPEC will evaluate supportive care interventions that are used routinely in intensive care units throughout the world.
CONDITIONS
Official Title
Canadian Critical Care Comparative Effectiveness Platform
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ongoing vasopressor infusion for hypotension or planned vasopressor use as part of usual care
- Mean arterial pressure less than 75 mmHg or lower than the highest local target range
- Expected ICU stay longer than 48 hours
- Adult patients aged 18 years or older admitted to ICU with platelet count less than 50 x 10^9/L
- Planned low-to-moderate bleeding risk invasive procedure
- Critically ill adults aged 18 years or older requiring invasive mechanical ventilation
- Presence of orogastric, nasogastric, or confirmed percutaneous gastric feeding tube
- Treating team has started or intends to provide enteral nutrition
You will not qualify if you...
- Treating team lacks equipoise for at least two contiguous MAP target ranges in the vasopressor domain
- Acute traumatic brain injury within 7 days or active treatment for raised intracranial pressure
- Acute subarachnoid hemorrhage within 21 days
- Acute spinal cord injury within 7 days or ongoing vasopressor therapy for spinal ischemia
- Lung, heart, liver, or kidney transplant recipient within 7 days
- More than 24 hours since meeting inclusion criteria in ICU
- Prior randomization in CEPEC vasopressor domain or confounding trial
- Ongoing major bleeding requiring blood products or surgical/radiological intervention
- Intracranial hemorrhage within prior 72 hours
- Contraindications to platelet transfusion (e.g., thrombotic microangiopathies, heparin-induced thrombocytopenia, immune thrombocytopenia, congenital platelet defects)
- Known advance decision refusing blood transfusions
- Acute promyelocytic leukemia
- Death perceived imminent or admission for palliation
- Prior randomization in CEPEC platelet domain or T4P trial
- Fulfilled all inclusion criteria for more than 72 hours
- Recent gastrointestinal surgery within 3 months not ready for bolus nutrition
- Active bowel obstruction or ischemia
- Presence of post-pyloric small bowel feeding tube
- Active gastrointestinal bleeding
- Chronic enteral nutrition use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Hamilton Health Sciences - Juravinski Hospital
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
2
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
3
Scarborough Health Network
Scarborough Village, Ontario, Canada, M1P 2V5
Actively Recruiting
4
Niagara Health
St. Catharines, Ontario, Canada, L2S 0A9
Actively Recruiting
5
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
6
CIUSSS de l'Estrie - CHUS
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
7
Auckland City Hospital
Auckland, New Zealand
Not Yet Recruiting
8
Intensive Care National Audit and Research Centre (coordinating centre for sites in UK. Sites to be determined)
London, United Kingdom
Not Yet Recruiting
Research Team
M
Marie-Helene Masse, RRT, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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