Actively Recruiting
Canadian Network for Autoimmune Liver Disease
Led by University Health Network, Toronto · Updated on 2021-06-07
2500
Participants Needed
15
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting the Canadian Network for Autoimmune Liver Disease (CaNAL), a long-term observational study involving patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. These rare, slowly progressing liver diseases can lead to serious complications like cirrhosis, liver cancer, liver failure, or premature death. The study aims to create a nationwide registry to better understand these diseases by collecting detailed patient data from major Canadian centers. This study does not involve any treatment interventions. Instead, it observes patients during their usual care visits across multiple centers. The registry gathers a wide range of information including patient characteristics, lab results, treatment responses, quality of life measures, environmental exposures, and transplant outcomes. It also aims to identify risk factors and biomarkers related to disease progression, treatment response, and outcomes post-transplant. Participants will be followed over time, with data collected regularly, including biochemical tests and patient-reported outcomes like quality of life and pruritus scales, for an average of six months or more. The primary outcome measured is liver transplant-free survival over up to six years or until death or transplant. This study supports better understanding of autoimmune liver diseases and will provide a platform for future targeted research and clinical trials.
CONDITIONS
Brief Title
Canadian Network for Autoimmune Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Primary Biliary Cholangitis and/or Autoimmune Hepatitis
- Age 18 years or older
You will not qualify if you...
- Younger than 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants who meet eligibility criteria based on diagnosis and age are enrolled.
Duration - Up to 6 years or until death/liver transplant
Participants who undergo routine care are observed through their regular standard of care visits to monitor liver transplant-free survival and biochemical values over time.
Participants attend routine healthcare visits as per their standard care schedule, typically every 6 months on average
Trial Site Locations
Total: 15 locations
1
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9
Not Yet Recruiting
2
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
3
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
Not Yet Recruiting
4
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Not Yet Recruiting
5
Health Sciences Centre
Winnipeg, Manitoba, Canada, R3A 1R9
Not Yet Recruiting
6
Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2Y9
Active, Not Recruiting
7
McMaster University Medical Centre
Hamilton, Ontario, Canada, L8S 4K1
Not Yet Recruiting
8
Kingston Health Sciences Centre (HDH Site)
Kingston, Ontario, Canada, K7L 5G2
Active, Not Recruiting
9
London Health Sciences Centre - University Hospital
London, Ontario, Canada, N6A 5A5
Actively Recruiting
10
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
11
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
12
Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
13
McMaster University Medical Centre
Montreal, Quebec, Canada, H4A 3J1
Not Yet Recruiting
14
Université de Sherbrooke
Sherbrooke, Quebec, Canada, J1G2E8
Actively Recruiting
15
Royal University Hospital
Saskatoon, Saskatchewan, Canada, S7N 0W8
Actively Recruiting
Research Team
S
Surain Roberts, AB
K
Kattleya Tirona, BA, CCRP
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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