Actively Recruiting
Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)
Led by Canadian Cancer Trials Group · Updated on 2026-03-27
720
Participants Needed
10
Research Sites
462 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cancer drugs which target the effects of abnormal gene changes are called 'targeted therapies'. This study, called PM.1 or CAPTUR, will include some targeted therapies that are currently available. The purpose of this study is to find out what are the effects on a patient and their cancer when they are given a targeted therapy drug that is specific to an abnormal gene change in their cancer.
CONDITIONS
Official Title
Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (18 years or older) patient with a histologically-proven incurable metastatic solid tumor (excluding primary brain tumors), multiple myeloma, or B cell non-Hodgkin lymphoma (excluding CLL, SLL, and HCL).
- No standard treatment known to prolong life or patient has refused such treatment.
- ECOG performance status between 0 and 2.
- Normal organ function including specified neutrophil counts, platelet levels, bilirubin, liver enzymes, and kidney function.
- Patients must have measurable disease.
- Results available from tumor genetic or protein testing showing a potentially actionable variant.
- Patient consent obtained according to local and regulatory standards.
- Patients accessible for treatment and follow-up at a participating center within reasonable geographic limits.
- Women and men of childbearing potential agree to use highly effective contraception.
You will not qualify if you...
- Patients with prior or concurrent malignancy that could interfere with safety or study assessment.
- Ongoing toxicity grade 2 or higher related to previous anti-tumor treatment, except certain corrected conditions and peripheral neuropathy below grade 3.
- Receiving any other anti-cancer therapy except supportive care medications or ongoing castration therapy started at least one month prior.
- Known active progressive brain metastases; previously treated brain metastases must be stable and without recent seizures.
- Clinically significant cardiac conditions including uncontrolled angina, arrhythmias, or symptomatic heart failure.
- Left ventricular ejection fraction below 40%.
- Stroke or acute myocardial infarction within three months prior.
- Acute gastrointestinal bleeding within one month prior.
- Other significant medical conditions judged by the physician to interfere with study participation.
- Lactating or nursing women.
- Not meeting drug-specific eligibility for the chosen targeted therapy.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
2
BCCA - Kelowna
Kelowna, British Columbia, Canada, V1Y 5L3
Actively Recruiting
3
BCCA - Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
4
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
5
London Health Sciences Centre Research Inc.
London, Ontario, Canada, N6A 5W9
Actively Recruiting
6
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
7
University Health Network
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
8
The Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
9
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada, S4T 7T1
Actively Recruiting
10
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Actively Recruiting
Research Team
J
Janet Dancey
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
14
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