Effects of a Tele-exercise Program on Fatigue and Physical Function in Young Adults Surviving Brain Tumors

What this Trial Is About

Researchers are investigating the effects of the RISE-YA tele-exercise intervention on cancer-related fatigue in young adults who have survived brain tumors. The study aims to test whether RISE-YA can improve fatigue, physical activity, and physical function in these survivors. Additionally, the trial explores the relationship of fatigue with biological markers like oxidative phosphorylation and inflammation, and how the intervention impacts these markers. The study also looks at quality of life, muscle mass, diet, and exercise adherence as exploratory outcomes. Participants will be randomly assigned to receive the RISE-YA intervention, which includes one-on-one energy conservation counseling, behavior coaching, and personalized strength and aerobic exercises delivered via videoconference. They will also participate in survivorship education discussions using a booklet from the National Cancer Institute. Calls with trainers occur twice weekly during weeks 1 to 6 and once weekly during weeks 7 to 12, each lasting one hour. Participants will have prescriptions for self-led exercise sessions as part of the program. Throughout the study, participants will be assessed at baseline, 12 weeks, and 24 weeks for cancer-related fatigue, physical activity levels, various physical function tests, and biomarkers related to inflammation and oxidative phosphorylation. Patient-reported outcomes such as health-related quality of life, dietary intake, muscle measurements, and exercise adherence will also be collected. The study will monitor participants over 24 weeks to evaluate changes due to the intervention and ensure safety and adherence.

Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention