Actively Recruiting
Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention
Led by M.D. Anderson Cancer Center · Updated on 2026-03-04
75
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
C
Cancer Prevention Research Institute of Texas
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying young adults aged 18 to 39 who have survived brain cancer and are experiencing cancer-related fatigue. This study evaluates the effects of a tele-exercise program called RISE-YA on reducing fatigue and improving physical activity and function. It also explores how fatigue relates to energy production and inflammation in the body, as well as the impact of the exercise program on these biological factors. Participants will be randomly assigned to one of two groups: the RISE-YA intervention group or an attention control group receiving survivorship education. The RISE-YA program includes energy conservation counseling, behavior coaching, and supervised exercise training remotely. Survivorship education involves weekly video calls lasting about 60 minutes during the first 6 weeks and once weekly in weeks 7 to 12. During the study, participants will be monitored for safety and any adverse events for about one year. Researchers will assess fatigue levels, physical activity, muscle mass, dietary intake, exercise adherence, and quality of life through questionnaires and physical measurements. Care teams will be informed of participants' involvement, and assessments will include regular check-ins and data collection throughout the study period.
CONDITIONS
Brief Title
Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently between the ages of 18 and 39 years
- Primary brain tumor diagnosed between ages 15 and 39 years
- Between 6 months and less than 5 years after curative treatment
- Treated with chemotherapy and radiation
- FACIT-Fatigue score of 43 or less
- Currently do less than 150 minutes of physical activity and fewer than 2 muscle-strengthening sessions per week
- Able to speak, read, and write English
- No exercise contraindications based on Physical Activity Readiness Questionnaire (PAR-Q+)
- Able to provide informed consent or assent
You will not qualify if you...
- Non-English speaking
- Safety screen failure for exercise
- Unstable or symptomatic cardiac or pulmonary disease
- Recent fracture or acute musculoskeletal injury preventing exercise
- History of chronic disease, secondary cancers, genetic syndromes, or recurrent disease needing brain re-irradiation
- Cognitive or major sensory deficits that interfere with research participation
- Pregnancy
- Prisoner status
- Documented developmental disorders or major psychotic illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants receive energy conservation counseling, behavior coaching, and exercise training through a tele-exercise intervention called RISE-YA, along with survivorship education via weekly video calls.
Weekly video calls for 12 weeks
Duration - Up to 1 year after treatment
Participants are monitored for safety and adverse events through study completion.
Periodic safety assessments
Trial Site Locations
Total: 1 location
1
The University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Michael Roth, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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