Actively Recruiting
Cannabidiol After Multi-Trauma for Pain and Opioid Therapy
Led by Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Updated on 2025-07-30
225
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this project is to investigate the therapeutic potential and safety of acute Cannabidiol (CBD) treatment on longitudinal pain symptoms, and to assess potential interactions with pain mediators including opioids and sex on CBD treatment response. To this end, this research protocol proposes a comprehensive translational approach including a placebo-controlled randomized clinical trial comparing two daily doses of CBD treatment administered for one month on pain relief. This study will also compare intervention conditions on inflammation markers, participant quality of life, sleep quality, depression, anxiety, cognition and orthopaedic function.
CONDITIONS
Official Title
Cannabidiol After Multi-Trauma for Pain and Opioid Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a long bone fracture of the lower or upper limb treated at Sacre-Coeur Hospital within one week of the accident
- Participants aged between 18 and 70 years
- Patients with or without surgical procedures
You will not qualify if you...
- Moderate or severe traumatic brain injury
- Diagnosis of schizophrenia, intellectual disability, bipolar disorder, major depression, or untreated sleep disorders
- History of alcohol or opioid misuse or abuse
- Severe kidney or liver impairment
- Pregnant, breastfeeding, or women not using accepted contraception or planning pregnancy
- History of adverse reactions to cannabis
- Taking warfarin, sildenafil, valproate, or opioids before injury
- Mild or absent pain in the 24 hours before recruitment (VAS score <30)
- Employment as transport drivers or heavy machinery operators
- Diagnosis of chronic pain, bone disease, or chronic inflammatory disease
- Not speaking French or English
- MoCA cognitive score less than 24
- Regular cannabis use more than 5 times a week
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Sacré-Coeur de Montréal
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
Research Team
L
Louis De Beaumont, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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