Study of Plant-Derived Cannabidiol CBD Effects on Regular Cannabis Concentrate Users Aged 25 to 60

What this Trial Is About

Researchers are evaluating the effects of plant-derived cannabidiol CBD on adults who regularly use cannabis concentrates but are not trying to reduce or stop their use. This randomized, placebo-controlled, dose-ranging trial aims to understand if CBD can reduce cannabis concentrate use, the subjective effects of cannabis, or cannabis craving over a four-week period. The study includes 120 frequent concentrate users who will participate in sessions conducted in a mobile laboratory. Participants will be randomly assigned to take either 200 mg or 400 mg of broad-spectrum CBD or a placebo daily for four weeks. Medication is taken orally with food twice a day, morning and evening. During the study, participants will complete three mobile lab sessions where cannabis use is monitored, blood samples are collected to measure THC and CBD levels, and subjective effects and craving are assessed. These sessions occur at the start, two weeks, and four weeks into the treatment. Throughout the study, researchers will measure changes in THC blood levels, cannabis use amounts, subjective intoxication, psychotomimetic symptoms, anxiety, negative feelings, and craving. Participants will provide blood samples before and after cannabis use in the mobile lab, and complete a cannabis cue reactivity test at two weeks. The total study duration for each participant is four weeks, during which safety and study adherence are closely monitored.

Cannabidiol and Cannabis Concentrate Users