Actively Recruiting
Cannabidiol Effects on Learning and Anxiety
Led by University of Connecticut · Updated on 2026-04-29
160
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of Cannabidiol (CBD) on fear learning and anxiety in college students who have high levels of social anxiety. This early phase 1 trial recruits undergraduates at the University of Connecticut who show elevated social anxiety on standard tests. The study aims to see if CBD can help reduce fear responses during a controlled fear conditioning experiment. Participants will undergo a fear conditioning test where they learn to associate one face with a mild wrist shock and another face with no shock. After learning, half of the participants will receive a single 600 mg dose of CBD isolate gel capsules, while the other half will receive placebo capsules. Following this, participants will be exposed to the faces again without shocks to measure how quickly and effectively their fear responses diminish. Throughout the study, researchers will monitor participants' electrodermal responses and subjective fear ratings using a visual scale to assess fear extinction. The primary outcome is the electrodermal activity measured over 20 minutes. The trial is randomized and double-blind, with all participants completing the study within a single session. Safety and response data will be collected during this time to evaluate how CBD affects anxiety and learning.
CONDITIONS
Brief Title
Cannabidiol Effects on Learning and Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18-50 years of age
You will not qualify if you...
- Difficulties seeing a computer screen
- Anyone currently taking CBD within the last 24 hours
- Anyone using any cannabis product within the last 24 hours
- Heart problems or heart disease
- A neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm
- Are currently pregnant or breast-feeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - One day
Participants receive a one-time dose of either 600 mg Cannabidiol Isolate Gel Capsules or placebo capsules.
1 visit (in-person)
Duration - 20 minutes
Participants are observed for effects on learning and anxiety including electrodermal activity for 20 minutes after dosing.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Connecticut
Storrs, Connecticut, United States, 06269-1020
Actively Recruiting
Research Team
R
Robert Astur, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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