Actively Recruiting
Cannabinoids and Biological Reactivity to Stress
Led by Florida State University · Updated on 2025-09-16
36
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
F
Florida State University
Lead Sponsor
W
Wayne State University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to test the impact of two drugs that produce temporary stress-like symptoms, both in isolation and together, on cannabis use motivation in individuals with Cannabis Use Disorder. The main questions it will answer are: 1. How do different forms of stress affect cannabis use motivation? 2. How do different forms of stress affect the body's natural cannabinoids? Researchers will compare a placebo to both drugs in isolation, as well as together, across four separate lab visits. Participants will: 1\) Complete a clinical screening interview (by phone or in-person) and visit the lab for a medical screening, and if eligible: a) Visit the lab four times where they will: i). Take one of four drug combinations ii). Complete an interview, questionnaires, and computerized tasks iii). Have their brain activity recorded with an EEG cap iv). Provide three blood samples
CONDITIONS
Official Title
Cannabinoids and Biological Reactivity to Stress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets criteria for current, moderate to severe Cannabis Use Disorder (CUD) as assessed by the Structured Clinical Interview (SCID) for DSM-5 during screening
- Engages in near-daily or daily cannabis use
- Provides a urine sample positive for THC
- Is in generally good health based on physical exam, EKG, and blood tests
- Provides written informed consent after being informed of study nature and risks
- Can read and write in English
You will not qualify if you...
- History of serious psychiatric problems such as psychosis or Bipolar Disorder I, or current Major Depressive Episode
- Current suicidal ideation
- Meets criteria for any other current moderate to severe substance use disorder besides CUD or Tobacco Use Disorder
- Positive urine drug screen for drugs other than THC at screening or any lab visit
- Has structural brain abnormalities, stroke, seizures, infectious disease, other neurological diseases, or head trauma causing unconsciousness
- History of cardiovascular diseases including myocardial infarction, chest pain, palpitations, edema, hypertension, abnormal resting heart rate
- Blood pressure outside systolic 80-140 mmHg or diastolic 50-90 mmHg
- History of serious respiratory illness such as cor pulmonale, dyspnea, orthopnea, tachypnea, or uncontrolled COPD or asthma
- Currently taking any daily psychotropic medication
- Currently taking specified cardiovascular or diuretic medications
- Pregnant or not using medically approved birth control if able to become pregnant
- Currently seeking or engaging in treatment for CUD or other substance use
- Intends to imminently quit cannabis use
- Has Blood-Injection-Injury Phobia based on Medical Fear Survey scores
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The BRAINS Lab at Florida State University
Tallahassee, Florida, United States, 32306-4301
Actively Recruiting
Research Team
M
Mallory Cannon, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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