Actively Recruiting
Prospective Changes in Patient-Reported and Objective Functioning Following Reduction of Cannabis Use
Led by Medical University of South Carolina · Updated on 2026-03-19
176
Participants Needed
1
Research Sites
19 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of reducing cannabis use in adults diagnosed with cannabis use disorder (CUD). The study aims to understand how decreasing cannabis consumption may improve cannabis-related problems, sleep quality, cognitive abilities, the severity of CUD, and overall quality of life. This interventional study is sponsored by the Medical University of South Carolina and focuses on adults 18 years and older with confirmed CUD. Participants will engage in an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives tied to reductions in urinary cannabinoid levels. The program begins with one therapist-led motivational session followed by seven computerized CBT sessions. Financial rewards are provided contingent on lowering cannabis use as measured by urine tests. Throughout the study, participants will be monitored for changes in cannabis-related problems, sleep patterns including total sleep time and sleep stages, and various cognitive functions assessed through standardized memory and processing speed tests. The primary outcome is measured at the end of the 8-week treatment, focusing on cannabis-related problems. This study involves regular assessments and aims to observe improvements in functioning and quality of life linked to cannabis use reduction.
CONDITIONS
Brief Title
Cannabis Reduction and Functional Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18+
- Urinary cannabinoid level ≥ 50 ng/mL
- DSM-5 diagnosis of cannabis use disorder (mild, moderate, or severe)
- Willingness to attempt cannabis reduction
- Completion of Intake Visit
You will not qualify if you...
- Serious medical or psychiatric conditions
- Pregnancy or breastfeeding
- Cannabis use in the past 30 days was for medical purposes only
- Discontinuation or reduction of cannabis use may worsen a pre-existing condition
- Cognitive or understanding difficulties preventing informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants receive one therapist-led motivational interviewing and goal setting session followed by 7 sessions of computerized cognitive behavioral therapy (CBT4CBT). They also receive financial incentives contingent on reduction in urinary cannabinoids.
Weekly visits for up to 8 weeks
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
R
Rachel Tomko, PhD
E
Erin McClure, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
0
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