Actively Recruiting
Randomized Controlled Trial of Varenicline to Treat Tobacco and Cannabis Co-Use (RECLAIM)
Led by Medical University of South Carolina · Updated on 2026-04-03
200
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the effectiveness of varenicline, compared to a placebo, for adults who regularly use both cigarettes and cannabis. The study focuses on supporting participants in quitting cigarettes and reducing or stopping cannabis use. It is conducted remotely by the Medical University of South Carolina, enrolling adults aged 18 and older who live in South Carolina and are interested in quitting or reducing their tobacco and cannabis consumption.
CONDITIONS
Brief Title
Cannabis-Tobacco Co-Use Treatment Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 and over (no upper age limit)
- Smoke at least 5 tobacco cigarettes per day on at least 20 of the past 30 days for the past 3 months
- Interested in quitting tobacco
- Interested in reducing or stopping cannabis use
- Positive test for cotinine and cannabis before enrollment
- Self-reported cannabis use on at least 3 days per week in the past 30 days
- Willing to take varenicline or placebo for 12 weeks
- Reside in South Carolina
You will not qualify if you...
- Significant or unstable medical, psychiatric, or substance use problems that affect safety or participation
- Pregnant or trying to become pregnant
- Use of medications for smoking cessation
- Regular use of e-cigarettes or other tobacco products on 10 or more days in the past month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote)
Duration - 12 weeks
Participants receive 12 weeks of treatment with either varenicline or placebo combined with weekly skills-based counseling and access to online psychosocial modules to support tobacco cessation and cannabis use reduction or abstinence.
Weekly remote visits for counseling and medication monitoring
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina - Charleston
Charleston, South Carolina, United States, 29403
Actively Recruiting
Research Team
E
Erin Mcclure
E
Elizabeth Chapman
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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