Actively Recruiting
Cannabis-Tobacco Co-Use Treatment Study
Led by Medical University of South Carolina · Updated on 2026-04-03
200
Participants Needed
1
Research Sites
190 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence and cannabis reduction or abstinence. All participants will also receive counseling and access to online treatment modules during a quit attempt for cigarettes and a reduction attempt for cannabis. This study is being conducted by the Medical University of South Carolina. All procedures are conducted remotely and there is no in-person visits are needed. To qualify, participants must be 18 or older, live in South Carolina, use cigarettes and cannabis, and are interested in quitting cigarettes and reducing cannabis.
CONDITIONS
Official Title
Cannabis-Tobacco Co-Use Treatment Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 and over (no upper age limit)
- Smoke at least 5 tobacco cigarettes per day on at least 20 of the past 30 days for the past 3 months
- Interested in quitting tobacco
- Interested in reducing or stopping cannabis use
- Positive instant-read test for cotinine and cannabis before enrollment
- Self-reported cannabis use (THC-dominant products) at least 3 days per week in the past 30 days
- Willing to take varenicline or placebo for 12 weeks
- Reside in South Carolina
You will not qualify if you...
- Significant or unstable medical, psychiatric, or substance use problems that affect safety or study participation
- Pregnant or trying to become pregnant
- Use of medications approved for smoking cessation
- Regular use of e-cigarettes or other tobacco products on 10 or more days in the past month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina - Charleston
Charleston, South Carolina, United States, 29403
Actively Recruiting
Research Team
E
Erin Mcclure
CONTACT
E
Elizabeth Chapman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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