Pilot Study Evaluating Supervised Cardiac Rehabilitation in Patients With Cardiac Amyloidosis

What this Trial Is About

Researchers are evaluating the effects of supervised cardiac rehabilitation exercise programs in patients with cardiac amyloidosis, a condition affecting heart function. The study aims to assess whether structured exercise can improve cardiorespiratory fitness and quality of life in these patients, focusing on those with heart failure classified as New York Heart Association Class I-III. This pilot study also intends to inform future treatment options and insurance coverage for cardiac rehabilitation in cancer and non-cancer populations. Participants are randomly assigned to one of two groups. The intervention group undergoes baseline fitness tests including a 6-minute walk test and cardiopulmonary exercise test (CPET), followed by a supervised cardiac rehabilitation program consisting of three one-hour exercise sessions per week for 12 weeks, totaling 36 sessions. After completing the program, these tests are repeated. The control group completes the same baseline tests but does not participate in the rehabilitation program and repeats the tests after 12 to 14 weeks. During the study, participants will be monitored for their ability to complete at least 75% of the prescribed exercise sessions. Researchers will measure changes in maximal oxygen uptake, ventilatory efficiency, exercise capacity via walk tests, chronotropic competence, and quality of life using the Kansas City Cardiomyopathy Questionnaire. The total participation includes initial assessments, the 12-week intervention or observation period, and follow-up testing within two weeks after program completion to evaluate outcomes and adherence.

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study