Actively Recruiting

Age: 18Years +
All Genders
NCT07232342

Capillary Leak Index Versus Conventional Biomarkers in Predicting Sepsis-Related Outcomes

Led by Benha University · Updated on 2025-11-18

100

Participants Needed

1

Research Sites

46 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study aims to evaluate the prognostic significance of CLI in predicting 28-day mortality and other outcomes in critically ill patients who develop post-operative abdominal sepsis.

CONDITIONS

Official Title

Capillary Leak Index Versus Conventional Biomarkers in Predicting Sepsis-Related Outcomes

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Postoperative secondary peritonitis requiring ICU admission with clinical evidence such as diffuse or localized abdominal pain or tenderness, peritoneal signs like guarding, rigidity, or rebound tenderness
  • Imaging or intraoperative confirmation of purulent or exudative intra-abdominal fluid
  • Evidence of systemic inflammation including fever, leukocytosis, or need for vasopressors
  • Sepsis diagnosis based on Sepsis-3 criteria with suspected or confirmed infection and acute SOFA score increase of 2 or more points
  • Expected ICU stay of at least 48 hours after surgery
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Advanced liver disease (Child-Pugh class B or C) affecting albumin levels
  • Advanced kidney disease (CKD stage 4 or 5) or patients on chronic dialysis
  • Expected death within 48 hours of ICU admission
  • Primary peritonitis or tertiary peritonitis
  • Immunocompromised status including chronic immunosuppressive therapy, organ transplant recipients, or HIV with CD4 count below 200/mm³
  • Pre-existing systemic inflammatory diseases affecting baseline CRP levels
  • Participation in other interventional trials that could affect outcomes

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Benha University Hospital

Banhā, Qalyubia Governorate, Egypt, 13511

Actively Recruiting

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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