Actively Recruiting
A Phase 3, Multicenter, Randomized, Double-Masked Study Comparing EYP-1901 to Aflibercept in Participants With Diabetic Macular Edema
Led by EyePoint Pharmaceuticals, Inc. · Updated on 2026-06-03
240
Participants Needed
62
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of EYP-1901, a tyrosine kinase inhibitor, compared to Aflibercept in treating diabetic macular edema (DME). This phase 3, randomized, double-masked study aims to assess how well these treatments improve vision in participants with DME, a condition related to diabetic retinopathy that affects the central part of the retina. Participants will receive intravitreal injections of either EYP-1901 or Aflibercept. The study is designed with parallel groups and a quadruple masking approach, meaning neither participants nor researchers will know which treatment is given. The treatments will be administered according to the study schedule, with monitoring throughout the trial period. During the study, participants will undergo assessments including measuring best corrected visual acuity (BCVA) at 52 and 56 weeks to evaluate changes in vision. The study will also track the rate of injections needed by week 56. Safety and treatment effects will be monitored throughout the trial, which is expected to continue until October 2028.
CONDITIONS
Brief Title
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with macular edema associated with diabetic retinopathy in the study eye
- Best corrected visual acuity (BCVA) score between 35 and 78 letters on the ETDRS chart in the study eye
- For previously treated patients, at least one anti-VEGF injection in the past 12 months, with the last injection at least 12 weeks before screening
You will not qualify if you...
- BCVA score less than 30 letters on the ETDRS chart (20/250 Snellen equivalent) in the fellow eye
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 56 weeks
Participants receive intravitreal injections of either EYP-1901 or Aflibercept as part of the study treatment for diabetic macular edema.
Visits for injections and assessments scheduled during the treatment period
Trial Site Locations
Total: 62 locations
1
Associated Retina Consultans
Gilbert, Arizona, United States, 85297
Actively Recruiting
2
Associated Retina Consultants - Phoenix
Phoenix, Arizona, United States, 85020
Actively Recruiting
3
Phoenix Retina Clinical Trials, LLC - North Phoenix
Phoenix, Arizona, United States, 85050
Actively Recruiting
4
Retina Macula Institute of Arizona
Scottsdale, Arizona, United States, 85255
Actively Recruiting
5
Retina Vitreous Associates Medical Group
Beverly Hills, California, United States, 90211
Actively Recruiting
6
Retina Consultants of Orange County
Fullerton, California, United States, 92835
Actively Recruiting
7
South Coast Retina Center
Long Beach, California, United States, 90807
Actively Recruiting
8
Retinal Consultants Medical Group - Modesto
Modesto, California, United States, 95356
Actively Recruiting
9
Kaiser Permanente
Oakland, California, United States, 94611
Actively Recruiting
10
Retina Consultants of Southern California
Redlands, California, United States, 92374
Actively Recruiting
11
Bay Area Retina Associates
Walnut Creek, California, United States, 94598
Actively Recruiting
12
Retina Specialists of Colorado - Arvada
Arvada, Colorado, United States, 80002
Actively Recruiting
13
Connecticut Eye Consultants, P.C.
Danbury, Connecticut, United States, 06810
Actively Recruiting
14
Coastal Eye Surgeons, LLC
Greenwich, Connecticut, United States, 06830
Actively Recruiting
15
Retina Group of New England, PC
Waterford, Connecticut, United States, 06385
Actively Recruiting
16
Retina Group of Florida - Fort Lauderdale
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
17
Retina Specialty Institute
Pensacola, Florida, United States, 32503
Actively Recruiting
18
Fort Lauderdale Eye Institute
Plantation, Florida, United States, 33324
Actively Recruiting
19
MedEye Associates
South Miami, Florida, United States, 33143
Actively Recruiting
20
Retina Vitreous Associates of Florida - Saint Petersburg
St. Petersburg, Florida, United States, 33711
Actively Recruiting
21
Retina Vitreous Associates of Florida
Tampa, Florida, United States, 33617
Actively Recruiting
22
Retina Associates
Elmhurst, Illinois, United States, 60126
Actively Recruiting
23
University Retina and Macula Associates
Lemont, Illinois, United States, 60439
Actively Recruiting
24
Illinois Retina Associates, S.C.
Oak Park, Illinois, United States, 60304
Actively Recruiting
25
Associated Vitreoretinal & Uveitis Consultants - Carmel
Carmel, Indiana, United States, 46032
Actively Recruiting
26
The Eye Care Institute
Louisville, Kentucky, United States, 40206
Actively Recruiting
27
Mid Atlantic Retina Specialists - Hagerstown
Hagerstown, Maryland, United States, 21740
Actively Recruiting
28
The Retina Institute
St Louis, Missouri, United States, 63128
Actively Recruiting
29
Retina Center of New Jersey
Bloomfield, New Jersey, United States, 07003
Actively Recruiting
30
Vision Research Center at Eye Associates of New Mexico
Albuquerque, New Mexico, United States, 87109
Actively Recruiting
31
Retina Vitreous Surgeons of CNY, PC
Liverpool, New York, United States, 13088
Actively Recruiting
32
Graystone Eye - Hickory Office
Hickory, North Carolina, United States, 28602
Actively Recruiting
33
North Carolina Retina Associates
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
34
Retina Vitreous Center, PLLC
Edmond, Oklahoma, United States, 73013
Actively Recruiting
35
Verum Research, LLC
Eugene, Oregon, United States, 97401
Actively Recruiting
36
Wills Eye Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
37
Carolinas Centers for Sight, P.C. - Florence Campus
Florence, South Carolina, United States, 29501
Actively Recruiting
38
Charles Retina Institute
Germantown, Tennessee, United States, 38138
Actively Recruiting
39
Austin Clinical Research LLC
Austin, Texas, United States, 78750
Actively Recruiting
40
Retina and Vitreous of Texas
Bellaire, Texas, United States, 77401
Actively Recruiting
41
Retina Consultants of Texas
Bellaire, Texas, United States, 77401
Actively Recruiting
42
San Antonio Eye Center
San Antonio, Texas, United States, 78215
Actively Recruiting
43
Retina Associates of South Texas
San Antonio, Texas, United States, 78240
Actively Recruiting
44
Retina Consultants of Texas
The Woodlands, Texas, United States, 77384
Actively Recruiting
45
Tyler Retina Consultants
Tyler, Texas, United States, 75703
Actively Recruiting
46
Strategic Clinical Research Group, LLC
Willow Park, Texas, United States, 76087
Actively Recruiting
47
The Retina Group of Washington
Fairfax, Virginia, United States, 22031
Actively Recruiting
48
Eye Clinic of Wisconsin
Wausau, Wisconsin, United States, 54403
Actively Recruiting
49
Retina Prime at Jardim Europa Medical Center
Aracaju, Brazil
Actively Recruiting
50
Centro Brasileiro de Pesquisa Clinica - Blumenau
Blumenau, Brazil
Actively Recruiting
51
IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia
São Paulo, Brazil
Actively Recruiting
52
Retina Clinic-Jardim America
São Paulo, Brazil
Actively Recruiting
53
Axon Clinical, s.r.o.
Prague, Czechia
Actively Recruiting
54
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia
Actively Recruiting
55
St Elisabeth Krankenhaus
Cologne, Germany
Actively Recruiting
56
Bajcsy-Zsilinszky Korhaz es Rendelointezet
Budapest, Hungary
Actively Recruiting
57
Budapest Retina Associates
Budapest, Hungary
Actively Recruiting
58
Semmelweis Egyetem
Budapest, Hungary
Actively Recruiting
59
Debreceni Egyetem KK Szemklinika
Debrecen, Hungary
Actively Recruiting
60
Ganglion Medical Center
Pécs, Hungary
Actively Recruiting
61
PTE KK Ophthalmology Clinic (Optimum Szemeszet)
Pécs, Hungary
Actively Recruiting
62
SzTE KK Szemeszeti Klinika
Szeged, Hungary
Actively Recruiting
Research Team
R
Ramiro Ribeiro, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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