Actively Recruiting
Capsaicin in Digital Osteoarthritis Versus Control
Led by University Hospital, Clermont-Ferrand · Updated on 2025-03-13
120
Participants Needed
4
Research Sites
147 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Clermont-Ferrand
Lead Sponsor
G
Grünenthal GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this multicentric, randomized controlled double-blind clinical trial is to demonstrate the efficacy of transdermal application of capsaicin in patients with painful digital osteoarthritis with a neuropathic pain component. Participants will receive either a transdermal patch of capsaicin 179 mg (8%) or the control treatment (capsaicin 0.04%). Researchers will compare the intensity of pain in the fingers at day 60 in the capsaicin 8% group versus capsaicin 0.04% (control arm)
CONDITIONS
Official Title
Capsaicin in Digital Osteoarthritis Versus Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of digital osteoarthritis fulfilling the American College of Rheumatology criteria
- Finger pain of 40 mm or higher on a visual analogue scale (VAS)
- Finger pain with neuropathic pain component (DN4 score 4/10 or higher)
- Inadequate response, adverse reactions, or contraindications to conventional analgesics and NSAIDs
You will not qualify if you...
- Isolated rhizarthrosis
- Other joint diseases affecting the fingers (gout, chondrocalcinosis, rheumatoid arthritis, spondyloarthritis, psoriatic arthritis)
- Upper extremity pain syndromes interfering with finger pain assessment
- Other causes of neuropathic hand pain (carpal tunnel syndrome, diabetic neuropathy, Guyon's tunnel syndrome, cervicobrachial neuralgia, brachial plexitis)
- Skin lesions on fingers (psoriasis, wounds, chronic ulcers, eczema, shingles, dermatitis)
- Poorly controlled high blood pressure
- Hypersensitivity to capsaicin
- Use of 8% capsaicin patch within the past year
- Recent corticosteroid therapy, disease-modifying anti-rheumatic treatment, or intra-articular injections to finger joints within 3 months
- Use of wrist or finger orthoses in the past month
- Diagnosis of fibromyalgia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Actively Recruiting
2
HCL Hôpital Edouard Herriot
Lyon, France
Actively Recruiting
3
AP-HP Hôpital Saint-Antoine
Paris, France
Actively Recruiting
4
CHU de Saint-Etienne
Saint-Etienne, France
Actively Recruiting
Research Team
L
Lise Laclautre
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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