Assessment of Capsule Sponge for Monitoring Treatment Response in Non-stenotic Eosinophilic Oesophagitis at a Single Hospital

What this Trial Is About

Researchers are evaluating the use of a Capsule sponge device as an alternative to traditional gastroscopy for monitoring treatment response in adults with non-stenotic eosinophilic oesophagitis (EOE). This condition causes swallowing difficulties and inflammation in the esophagus, and current monitoring requires repeated invasive gastroscopies. The study aims to see if the Capsule sponge provides enough information to guide treatment decisions while assessing patient preference and symptom correlation with eosinophil counts. The Capsule sponge is a pill on a string that collects esophageal cells after being swallowed, allowing for cytological analysis of eosinophil levels and inflammation markers. Patients who have had a change in treatment will be offered this device instead of gastroscopy. Participants will complete a symptom questionnaire for two weeks before the procedure, undergo the Capsule sponge sampling, and then have a follow-up clinic visit about 6-8 weeks later. The study also tracks patient satisfaction, procedure success rates, complications, and possible cost savings. During the study, patients will complete self-administered symptom questionnaires and surveys on satisfaction and pain related to the procedure. The collected samples are analyzed for eosinophil counts and other relevant markers. Researchers will record changes in clinical management based on Capsule sponge findings and follow patients for about one year to observe outcomes like gastroscopy rates and treatment adjustments. The study will enroll 100-140 adults over two years, gathering real-world data on this less invasive monitoring method.

Capsule Sponge Study in Eosinophilic Oesophagitis