Actively Recruiting
CAR T-cell Long-Term Follow-Up, Quality of Life and Adverse Reactions
Led by St. Jude Children's Research Hospital · Updated on 2026-04-29
80
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To learn more about the long-term health in patients treated for B-Cell Acute Lymphoblastic Leukemia (B-ALL) with Cluster of Differentiation antigen 19 (CD19) -redirected chimeric antigen receptor (CAR) T-cells. Primary Objective: To evaluate the feasibility of conducting standardized clinical assessments of pediatric, adolescent and young adult (AYA) B-ALL survivors post CD19-CAR T-cell therapy, treated at multiple institutions, leveraging the St Jude Lifetime Cohort (SJLIFE) clinical and research infrastructure. Exploratory Objectives: * To describe the prevalence of persistent and new/late-onset health conditions developing ≥2-years post CD19-CAR T-cell therapy in survivors of pediatric and AYA B-ALL. * To characterize neurocognitive and neurologic function in survivors ≥2-years post CD19- CAR T-cell therapy. * To characterize immune health in survivors ≥2-years post CD19-CAR T-cell therapy. * To characterize functional status in survivors ≥2-years post CD19-CAR T-cell therapy.
CONDITIONS
Official Title
CAR T-cell Long-Term Follow-Up, Quality of Life and Adverse Reactions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 26 years old or younger at the time of the first CAR treatment
- Received a CD19-containing CAR T-cell product for B-ALL
- Received one unique CAR product (reinfusion of the same product is allowed)
- In sustained remission without additional therapy after CAR treatment (except post-CAR transplant)
- Received only one prior hematopoietic cell transplant before or after CAR therapy
- At least 2 years have passed since the last CAR T-cell infusion
You will not qualify if you...
- Unable or unwilling to provide written informed consent by the participant or legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
A
Aimee Talleur, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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