Actively Recruiting
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
Led by Sheba Medical Center · Updated on 2026-05-08
120
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems. In this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery. The main questions this study aims to answer are: * Does giving carbetocin after delivery lower blood loss compared with standard oxytocin treatment? * Is carbetocin safe and practical to use in twin deliveries? Researchers will compare carbetocin to standard oxytocin treatment to see which approach better prevents bleeding after twin vaginal or cesarean delivery. Participants will: * Be randomly assigned to receive either carbetocin or standard oxytocin after the second twin is delivered * Have blood tests before delivery and on the day after delivery * Be followed during their hospital stay and for up to six weeks after delivery for safety outcomes
CONDITIONS
Official Title
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant individuals aged ≥18 years
- Twin pregnancies
- Gestational age ≥23 weeks
You will not qualify if you...
- Known hypersensitivity or contraindication to carbetocin
- Higher-order multiple gestation (triplets or more)
- Maternal age <18 years
- Known placenta accreta spectrum
- Known bleeding disorder
- Intrauterine fetal death of one or more fetuses
- Hyponatremia precluding oxytocin use
- Planned delivery at a non-participating hospital
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sheba Medical Center
Ramat Gan, Israel, 5262000
Actively Recruiting
Research Team
A
Avihu Krieger, MD
CONTACT
T
Tal Cahan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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