Actively Recruiting
Carbon Dioxide Administration and Brain Waste Clearance
Led by Andrew Mayer · Updated on 2026-02-23
200
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.
CONDITIONS
Official Title
Carbon Dioxide Administration and Brain Waste Clearance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to give valid informed consent
- Aged 18 to 82 years
- For TBI group: history of traumatic brain injury of any severity sustained at age 18 or older, confirmed by semi-structured interview
- For healthy group: no history of TBI
You will not qualify if you...
- Contraindications to MRI scanning including pregnancy or claustrophobia
- Unable to give valid informed consent or incarcerated
- Diagnosed with Alzheimer's disease, ADRD, or mild cognitive impairment
- History of autism spectrum disorder, intellectual disability, serious neurological conditions (e.g., epilepsy, tumors, neurosurgery) or psychiatric disorders requiring hospitalization prior to TBI onset (for TBI group)
- Current or previous diagnosis of psychosis spectrum or bipolar disorder (for TBI group)
- Respiratory diseases or pulmonary conditions increasing study risk (e.g., severe asthma, COPD)
- History of cardiac arrhythmias
- Current or past substance use disorder or regular substance use in past six months (healthy group)
- Previous head injury with loss of consciousness over 30 minutes (healthy group)
- Non-English fluency
- Weigh under 110 pounds (blood draw requirement)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Mind Research Network
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
Research Team
J
Jody Roberts, MS
CONTACT
A
Andrew Mayer R The Mind Research Network, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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