Actively Recruiting

Phase Not Applicable
Age: 18Years - 99Years
All Genders
NCT04134754

Carbon Dioxide (CO2) Chemosensitivity and SUDEP

Led by University of Iowa · Updated on 2026-03-09

335

Participants Needed

1

Research Sites

511 weeks

Total Duration

On this page

Sponsors

U

University of Iowa

Lead Sponsor

N

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or sense elevated carbon dioxide (CO2) levels when breathing is impaired. Subjects will be followed for ten years after enrollment to monitor their health.

CONDITIONS

Official Title

Carbon Dioxide (CO2) Chemosensitivity and SUDEP

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Between 18 and 99 years old
  • Confirmed or suspected epilepsy
  • Admitted to the Epilepsy Monitoring Unit for seizure evaluation or receiving care at the University of Iowa Epilepsy Clinic
Not Eligible

You will not qualify if you...

  • History of uncontrolled heart, lung, or liver disease
  • Progressive or uncontrolled neurological disease unrelated to epilepsy
  • Current opioid use
  • Pregnant women or women able to become pregnant without effective birth control
  • Other health conditions that make HCVR testing unsafe or not feasible
  • Limited decision-making ability without a qualified representative

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States, 52242

Actively Recruiting

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Research Team

S

Study Coordinator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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