Actively Recruiting

Phase 2
Age: 18Years - 80Years
All Genders
NCT05613452

Carbon Ion Therapy for Peripheral Non-small Cell Lung Cancer

Led by Shanghai Proton and Heavy Ion Center · Updated on 2025-06-13

43

Participants Needed

1

Research Sites

117 weeks

Total Duration

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AI-Summary

What this Trial Is About

To investigate the efficacy of carbon ion therapy for stage Ia-IIa primary peripheral non-small cell lung cancer (NSCLC). The primary endpoint was progression-free survival (PFS), and the secondary endpoint was local control rate, overall survival (OS) and toxicities.

CONDITIONS

Official Title

Carbon Ion Therapy for Peripheral Non-small Cell Lung Cancer

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Between the ages of 18 and 80.
  • ECOG general status score of 0-2.
  • Primary non-small cell lung cancer confirmed by histology or cytology, stage Ia-IIa (T1-2N0M0).
  • Tumor located peripherally at least 2 cm from esophagus, main bronchial tree, spinal cord, heart, great blood vessels, brachial plexus, and stomach, and at least 1 cm from chest wall.
  • Medically inoperable or patient refuses surgery.
  • Adequate organ function including blood counts, lung function (FEV1 >25%, DLCO >25%), cardiac function without serious complications, liver function within specified limits, and renal function within specified limits.
  • Signed informed consent.
Not Eligible

You will not qualify if you...

  • Multiple primary tumors.
  • Failure to comply with treatment protocol.
  • Other uncontrolled malignant tumors.
  • Inability to meet particle radiotherapy planning requirements.
  • Prior chest radiation therapy or radioactive particle implantation.
  • Presence of cardiac pacemakers or internal metal prostheses affecting radiation.
  • Pregnancy or lactation.
  • HIV positive or active viral infections requiring therapy but unable to receive it.
  • History of mental illness interfering with treatment.
  • Serious comorbidities interfering with radiotherapy, including acute infections, recent heart events, respiratory hospitalizations, impaired immune function, radiation sensitivity diseases, or other relevant conditions.
  • Any other physician-determined reasons making participation inappropriate.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Shanghai Proton and Heavy Ion Center

Shanghai, Shanghai Municipality, China, 201513

Actively Recruiting

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Research Team

J

Jing Li

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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