Actively Recruiting
Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-01-07
59
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if the combination of the three anti-cancer drugs carboplatin, paclitaxel, and ramucirumab is helpful in shrinking tumors or delaying tumor growth in participants with non-small cell lung cancer. This study will also assess whether it is safe to combine these drugs.
CONDITIONS
Official Title
Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with advanced non-squamous NSCLC (Stage IV or recurrent after initial curative intent therapy)
- Previous treatment with 4-6 cycles of pemetrexed, carboplatin, and/or pembrolizumab
- Disease progression after at least 18 weeks of maintenance therapy with pemetrexed, pembrolizumab, or their combination
- Performance status (PS) of 0-1
You will not qualify if you...
- Presence of a driver mutation that can be treated with targeted therapy
- Having another active invasive cancer that requires ongoing treatment
- Sensory neuropathy of grade 2 or higher
- Untreated brain metastases
- History of bleeding disorders or recent significant coughing up of blood (more than half a teaspoon in the past 2 months)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Melissa Volpe, BA
CONTACT
M
Melina Marmarelis, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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