Completed
Phase 3
Age: 18Years - 75Years
All Genders
ID00000464
Led by University of Washington · Updated on 2013-07-29
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
To compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals who had survived one episode of out-of-hospital cardiac arrest.
CONDITIONS
Official Title
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
Who Can Participate
Age: 18Years - 75Years
All Genders
Eligibility Criteria
You may qualify if you...
Men and women with ventricular fibrillation who had survived an out-of-hospital cardiac arrest not associated with a Q-wave acute myocardial infarction.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Sudden arrhythmic cardiac death--mechanisms, resuscitation and classification: the Seattle perspective.
H L Greene
https://pubmed.ncbi.nlm.nih.gov/2404396Long-term outcome in patients who survive out of hospital ventricular fibrillation and undergo electrophysiologic studies: evaluation by electrophysiologic subgroups.
J E Poole, T L Mathisen, P J Kudenchuk...
https://pubmed.ncbi.nlm.nih.gov/2387939Signal-averaged electrocardiographic late potentials in resuscitated survivors of out-of-hospital ventricular fibrillation.
G L Dolack, D B Callahan, G H Bardy...
https://pubmed.ncbi.nlm.nih.gov/2330894Transvenous defibrillation in humans via the coronary sinus.
G H Bardy, M D Allen, R Mehra...
https://pubmed.ncbi.nlm.nih.gov/2317907Electrode system influence on biphasic waveform defibrillation efficacy in humans.
G H Bardy, C Troutman, G Johnson...
https://pubmed.ncbi.nlm.nih.gov/1860210Randomized antiarrhythmic drug therapy in survivors of cardiac arrest (the CASCADE Study). The CASCADE Investigators.
https://pubmed.ncbi.nlm.nih.gov/8342505Clinical predictors of implantable cardioverter-defibrillator shocks (results of the CASCADE trial). Cardiac Arrest in Seattle, Conventional versus Amiodarone Drug Evaluation.
G L Dolack
https://pubmed.ncbi.nlm.nih.gov/8296753The CASCADE Study: randomized antiarrhythmic drug therapy in survivors of cardiac arrest in Seattle. CASCADE Investigators.
H L Greene
https://pubmed.ncbi.nlm.nih.gov/8237833Rehospitalization in surviving patients of out-of-hospital ventricular fibrillation (the CASCADE Study). Cardiac Arrest in Seattle: Conventional Amiodarone Drug Evaluation.
C Maynard
https://pubmed.ncbi.nlm.nih.gov/8256707