Diagnosing Preclinical Cardiac Dysfunction in Swiss Childhood Cancer Survivors: Protocol for a Single-Center Cohort Study.
Christina Schindera, Claudia Elisabeth Kuehni, Mladen Pavlovic...
https://pubmed.ncbi.nlm.nih.gov/32269016Actively Recruiting
Age: 18Years +
All Genders
ID03790943
Prospective Single Center Cohort Study for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
Led by University of Bern · Updated on 2026-05-29
500
Participants Needed
6
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Bern
Lead Sponsor
U
University Hospital, Basel, Switzerland
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research investigates early heart dysfunction in adults who survived childhood cancer. It focuses on detecting heart problems sooner using a new echocardiographic method called speckle tracking compared to standard echocardiography. The study aims to improve early diagnosis of heart issues, which are a leading cause of death unrelated to cancer in this group. Participants receive detailed heart evaluations including conventional and speckle tracking echocardiography, cardiopulmonary exercise testing, and other assessments such as physical exams and questionnaires about lifestyle and fatigue. The study compares survivors treated with potentially heart-affecting therapies like anthracyclines or chest radiation (high risk) to those treated with other chemotherapy (standard risk). During the study visit, survivors undergo a thorough cardiac assessment with tests like electrocardiograms, exercise tests, and quality of life surveys. Researchers measure the presence of heart dysfunction and impaired exercise capacity, and evaluate treatment-related risk factors. Follow-up evaluations may be performed if clinically needed. The study is conducted at the University Hospital Bern, Switzerland, and participation requires written consent with no upper age limit specified.
CONDITIONS
Brief Title
Cardiac Dysfunction in Childhood Cancer Survivors
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Registered in the Childhood Cancer Registry
- Treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
- Treated with any chemotherapy and/or chest radiation
- Survived at least 5 years since most recent cancer diagnosis
- Diagnosed at age 20 years or younger
- At least 18 years old at time of study participation
- Resident in Switzerland
- Provided written informed consent
You will not qualify if you...
- Not meeting all inclusion criteria
- Refusal to participate in the study
AI-Screening
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Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a detailed cardiac assessment including personal history, physical examination, electrocardiogram, echocardiography, exercise testing, and questionnaires on health and lifestyle.
1 visit (in-person)
Long-term Monitoring
Duration - Ongoing as clinically indicated
Participants are monitored longitudinally based on clinical indications to detect any cardiac dysfunction over time.
Follow-up visits as needed depending on clinical findings
Trial Site Locations
Total: 6 locations
1
Department of Cardiology, University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031
Actively Recruiting
2
Institute of Social and Preventive Medicine, University of Bern
Bern, Canton of Bern, Switzerland, 3012
Active, Not Recruiting
3
Department of Cardiology, Inselspital Bern
Bern, Switzerland, 3010
Actively Recruiting
4
Department of Cardiology, University Hospitals of Geneva
Geneva, Switzerland, 1205
Actively Recruiting
5
Department of Cardiology, Lucerne Cantonal Hospital
Lucerne, Switzerland, 6000
Actively Recruiting
6
Department of Cardiology, Cantonal Hospital of St. Gallen
Sankt Gallen, Switzerland, 9007
Actively Recruiting
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Research Team
C
Claudia E Kuehni, MD
C
Christina Schindera, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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