Developing a Clinical Prediction Model Using Advanced Cardiac MRI for Early Risk Detection in Dilated Cardiomyopathy Patients

What this Trial Is About

Dilated cardiomyopathy DCM is a serious heart condition where the left ventricle enlarges and weakens, leading to poor heart function and risks like heart failure, arrhythmia, hospitalizations, and death. This observational study aims to develop and validate a clinical prediction model that helps identify which DCM patients are at higher risk of these severe outcomes by using advanced imaging and clinical data. The model will improve doctors ability to provide targeted care and reduce unnecessary treatments. The study uses multi-parameter stress perfusion cardiac magnetic resonance MP stress perfusion CMR, a safe and detailed imaging technique that evaluates heart structure, blood flow, and tissue damage under mild stress. This imaging data, combined with standard clinical information such as age, gender, blood pressure, and routine heart test results, will be analyzed from hundreds of DCM patients. The model will be trained and tested on this data to find patterns linked to adverse outcomes and then used to provide personalized risk scores for patients. Participants will undergo standard medical care including the CMR scan, which is non-invasive and commonly used. Researchers will follow patients over time to track outcomes like sudden cardiac death and heart failure at 1, 3, and 5 years after the scan. The study monitors these outcomes to validate the models accuracy and to better understand DCM progression. This will help doctors prioritize early interventions and monitoring for high-risk patients while improving overall treatment strategies and patient quality of life.

Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy