Actively Recruiting
Comprehensive Cardiac Magnetic Resonance Imaging Evaluation of Myocardial Scar for Predicting Sudden Cardiac Death Post Myocardial Infarction
Led by Beijing Anzhen Hospital · Updated on 2025-08-22
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether the characteristics of myocardial scar tissue, seen through cardiac magnetic resonance (CMR) imaging, can predict the risk of sudden cardiac death (SCD) after a heart attack (myocardial infarction, MI). This study focuses on improving risk prediction beyond current methods that mainly use heart function measures, by developing a combined imaging and clinical risk score. The study includes patients who had CMR scans during their stable recovery phase after MI and follows them to assess outcomes. This observational study has two phases: a retrospective phase reviewing patient records and CMR scans from 2015 to 2025, and a prospective phase collecting follow-up data from 2026 through 2036. Prognostic information is gathered mainly through clinic visits and telephone interviews every six months. The study tracks events related to sudden cardiac death, such as resuscitated cardiac arrests and device therapies, as well as other outcomes like overall mortality and heart failure hospitalizations. Participants will be monitored regularly over 10 to 20 years, with data collected on survival, cardiac events, and device interventions. Researchers will use CMR-determined scar features alongside clinical data to evaluate their ability to predict sudden cardiac death risk. Safety and ongoing health will be observed during follow-up visits, and the study aims to provide better tools for identifying patients who might benefit from preventive therapies after MI.
CONDITIONS
Brief Title
Cardiac Magnetic Resonance - PROgnostic HEart Scar for Sudden Cardiac Death Prediction StudY
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Completion of cardiac magnetic resonance (CMR) imaging at Anzhen Hospital during the stable phase (≥1 month) following an acute myocardial infarction (MI)
You will not qualify if you...
- Prior implantation of an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) before the index MI
- Pre-existing diagnosis of a primary arrhythmia syndrome (e.g., long QT syndrome, Brugada syndrome) before the index MI
- Concurrent end-stage disease (e.g., advanced malignancy) with estimated life expectancy less than one year
- History of established non-ischemic cardiomyopathy (e.g., dilated, hypertrophic, or restrictive cardiomyopathy) before the index MI
- Significant concomitant valvular heart disease or status post mechanical heart valve replacement
- Patients who refuse to be followed up
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Retrospective phase covering patients imaged between 2015 and 2025
Participants have already undergone cardiac magnetic resonance (CMR) imaging during clinical care after their myocardial infarction to assess myocardial scar characteristics.
No additional visits; imaging was completed prior to enrollment
Duration - Up to 10 years of follow-up (2026 through 2036)
Participants are followed prospectively with clinic visits and telephone interviews every 6 months to collect prognostic data related to sudden cardiac death and other cardiovascular outcomes.
Clinic visits and telephone interviews every 6 months
Trial Site Locations
Total: 1 location
1
Beijing Anzhen Hospital
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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